Christopher M Sassetti
Overview
Explore the profile of Christopher M Sassetti including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
112
Citations
7960
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Simwela N, Jaecklein E, Sassetti C, Russell D
Elife
. 2025 Mar;
13.
PMID: 40080408
() infection of macrophages reprograms cellular metabolism to promote lipid retention. While it is clearly known that intracellular utilize host-derived lipids to maintain infection, the role of macrophage lipid processing...
2.
Oluoch P, Koh E, Proulx M, Reames C, Papavinasasundaram K, Murphy K, et al.
Proc Natl Acad Sci U S A
. 2025 Feb;
122(9):e2417525122.
PMID: 39993187
Successful tuberculosis therapy requires treatment with an unwieldy multidrug combination for several months. Thus, there is a growing need to identify novel genetic vulnerabilities that can be leveraged to develop...
3.
Pullen K, Finethy R, Ko S, Reames C, Sassetti C, Lauffenburger D
NPJ Syst Biol Appl
. 2025 Feb;
11(1):19.
PMID: 39955299
Numerous studies have identified similarities in blood transcriptomic signatures of tuberculosis (TB) phenotypes between mice and humans, including type 1 interferon production and innate immune cell activation. However, murine infection...
4.
Luna M, Oluoch P, Miao J, Culviner P, Papavinasasundaram K, Jaecklein E, et al.
mBio
. 2025 Jan;
16(3):e0376224.
PMID: 39873486
Importance: (Mtb) is responsible for more deaths worldwide than any other single infectious agent. Understanding how this pathogen adapts to the varied environmental pressures imposed by host immunity and antibiotics...
5.
Simwela N, Johnston L, Bitar P, Jaecklein E, Altier C, Sassetti C, et al.
Nat Commun
. 2024 Oct;
15(1):9322.
PMID: 39472457
The eukaryotic Glucose Induced Degradation/C-Terminal to LisH (GID/CTLH) complex is a highly conserved E3 ubiquitin ligase involved in a broad range of biological processes. However, a role of this complex...
6.
Oluoch P, Koh E, Proulx M, Reames C, Papavinasasundaram K, Murphy K, et al.
bioRxiv
. 2024 Sep;
PMID: 39282290
Significance: The inevitable rise of multi-drug-resistant tuberculosis underscores the urgent need for new TB drugs and novel drug targets while prioritizing synergistic drug combinations. Chemical-genetic interaction (CGI) studies have delineated...
7.
Blanchard M, Sigmon J, Brennan J, Ahulamibe C, Allen M, Ardery S, et al.
G3 (Bethesda)
. 2024 Sep;
14(10).
PMID: 39271181
The MiniMUGA genotyping array is a popular tool for genetic quality control of laboratory mice and genotyping samples from most experimental crosses involving laboratory strains, particularly for reduced complexity crosses....
8.
Mittal E, Prasad G, Upadhyay S, Sadadiwala J, Olive A, Yang G, et al.
Nat Microbiol
. 2024 Sep;
9(11):2970-2984.
PMID: 39242815
Mycobacterium tuberculosis (Mtb) infects several lung macrophage populations, which have distinct abilities to restrict Mtb. What enables Mtb survival in certain macrophage populations is not well understood. Here we used...
9.
Simwela N, Jaecklein E, Sassetti C, Russell D
bioRxiv
. 2024 Aug;
PMID: 39091727
infection of macrophages reprograms cellular metabolism to promote lipid retention. While it is clearly known that intracellular utilize host derived lipids to maintain infection, the role of macrophage lipid processing...
10.
Simwela N, Johnston L, Bitar P, Jaecklein E, Altier C, Sassetti C, et al.
bioRxiv
. 2024 May;
PMID: 38766174
Graphical Abstract: