Tawnya C McKee
Overview
Explore the profile of Tawnya C McKee including associated specialties, affiliations and a list of published articles.
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29
Citations
433
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0
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Recent Articles
1.
Ossandon M, Agrawal L, Bernhard E, Conley B, Dey S, Divi R, et al.
J Natl Cancer Inst
. 2018 Jun;
110(9):929-934.
PMID: 29931312
The importance of circulating free DNA (cfDNA) in cancer clinical research was recognized in 1994 when a mutated RAS gene fragment was detected in a patient's blood sample. Up to...
2.
Bermingham A, Price E, Marchand C, Chergui A, Naumova A, Whitson E, et al.
SLAS Discov
. 2017 Jul;
22(9):1093-1105.
PMID: 28697309
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an enzyme crucial for cleavage of the covalent topoisomerase 1-DNA complex, an intermediate in DNA repair. TDP1 plays a role in reversing inhibition of topoisomerase...
3.
Chan S, Nani R, Schauer E, Martin G, Williamson R, Sauri J, et al.
J Org Chem
. 2016 Dec;
81(22):10631-10640.
PMID: 27934476
An extract of Eudistoma sp. provided eudistidine C (1), a heterocyclic alkaloid with a novel molecular framework. Eudistidine C (1) is a racemic natural product composed of a tetracyclic core...
4.
Goey A, Chau C, Sissung T, Cook K, Venzon D, Castro A, et al.
J Nat Prod
. 2016 May;
79(5):1267-75.
PMID: 27140429
Inhibition of the hypoxia-inducible factor 1α (HIF-1α) pathway by disrupting its association with the transcriptional coactivator p300 inhibits angiogenesis and tumor development. Development of HIF-1α/p300 inhibitors has been hampered by...
5.
Chan S, Patel P, Ransom T, Henrich C, McKee T, Goey A, et al.
J Am Chem Soc
. 2015 Apr;
137(16):5569-75.
PMID: 25892103
Low oxygen environments are a hallmark of solid tumors, and transcription of many hypoxia-responsive genes needed for survival under these conditions is regulated by the transcription factor HIF-1 (hypoxia-inducible factor...
6.
McKee T, Tricoli J
Methods Mol Biol
. 2014 Nov;
1238:217-34.
PMID: 25421662
The introduction of novel technologies that can be applied to the investigation of the molecular underpinnings of human cancer has allowed for new insights into the mechanisms associated with tumor...
7.
Jayatunga M, Thompson S, McKee T, Chan M, Reece K, Hardy A, et al.
Eur J Med Chem
. 2014 Jul;
94:509-16.
PMID: 25023609
Protein-protein interactions between the hypoxia inducible factor (HIF) and the transcriptional coactivators p300/CBP are potential cancer targets due to their role in the hypoxic response. A natural product based screen...
8.
McKee T, Rabe D, Bokesch H, Grkovic T, Whitson E, Diyabalanage T, et al.
J Nat Prod
. 2012 Aug;
75(9):1632-6.
PMID: 22928967
Renal or kidney cancer accounts for about 3% of all cancer cases reported each year in the U.S. Molecular signatures that define the cancer, such as the loss of functional...
9.
Whitson E, Sun H, Thomas C, Henrich C, Sayers T, McMahon J, et al.
J Nat Prod
. 2012 Feb;
75(3):394-9.
PMID: 22313254
Barleria alluaudii and Diospyros maritima were both investigated as part of an ongoing search for synergistic TRAIL (tumor necrosis factor-α-related apoptosis-inducing ligand) sensitizers. As a result of this study, two...
10.
Popplewell W, Ratnayake R, Wilson J, Beutler J, Colburn N, Henrich C, et al.
J Nat Prod
. 2011 Aug;
74(8):1686-91.
PMID: 21806011
Grassypeptolides F (1) and G (2), bis-thiazoline-containing cyclic depsipeptides with a rare β-amino acid, extensive N-methylation, and a large number of d-amino acids, are reported from an extract of the...