Tawnya C McKee
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Explore the profile of Tawnya C McKee including associated specialties, affiliations and a list of published articles.
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29
Citations
433
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Recent Articles
11.
Whitson E, Pluchino K, Hall M, McMahon J, McKee T
Org Lett
. 2011 Jun;
13(13):3518-21.
PMID: 21644548
Extracts of the sponge genus Candidaspongia showed selective cytotoxicity toward melanoma cells in the NCI 60-cell-line screen. Continued investigation of the Candidaspongia sp. extracts led to the isolation of three...
12.
Van Wyk A, Zuck K, McKee T
J Nat Prod
. 2011 Apr;
74(5):1275-80.
PMID: 21488653
Lithothamnin A (1) is a new bastadin-like metabolite and represents the first report of this class of molecules from the red alga Lithothamnion fragilissimum. Lithothamnin A contains several novel structural...
13.
Grkovic T, Whitson E, Rabe D, Gardella R, Bottaro D, Linehan W, et al.
Bioorg Med Chem Lett
. 2011 Mar;
21(7):2113-5.
PMID: 21353547
Kidney cancer was the cause of almost 13,000 deaths in the United States in 2009. Loss of function of the VHL tumor suppressor gene (von Hippel-Lindau disease) dramatically increases the...
14.
Whitson E, Thomas C, Henrich C, Sayers T, McMahon J, McKee T
J Nat Prod
. 2010 Nov;
73(12):2013-8.
PMID: 21067210
Casearia arguta was investigated as part of the ongoing search for synergistic TRAIL (tumor necrosis factor-α-related apoptosis-inducing ligand) sensitizers. As a result of this study, argutins A-H, eight new highly...
15.
Bokesch H, Cartner L, Fuller R, Wilson J, Henrich C, Kelley J, et al.
Bioorg Med Chem Lett
. 2010 Jul;
20(13):3848-50.
PMID: 20627559
Five new naphthopyrones (1-5) along with the known compounds TMC-256A1, 5,8-dihydroxy-6-methoxy-2-propyl-4H-naphtho[2,3-b]pyran-4-one, TMC-256C1, comaparvin, 6-methoxycomaparvin, and 6-methoxycomaparvin 5-methyl ether (6-11) were isolated from crinoids of the family Comasteridae. All compounds were...
16.
Beutler J, Kang M, Robert F, Clement J, Pelletier J, Colburn N, et al.
J Nat Prod
. 2009 Feb;
72(3):503-6.
PMID: 19199792
Several quassinoids were identified in a high-throughput screening assay as inhibitors of the transcription factor AP-1. Further biological characterization revealed that while their effect was not specific to AP-1, protein...
17.
Clement J, Kitagaki J, Yang Y, Saucedo C, OKeefe B, Weissman A, et al.
Bioorg Med Chem
. 2008 Nov;
16(23):10022-8.
PMID: 18977148
Compounds that stabilize p53 could suppress tumors providing a additional tool to fight cancer. Mdm2, and the human ortholog, Hdm2 serve as ubiquitin E3 ligases and target p53 for ubiquitylation...
18.
Bokesch H, Wamiru A, Le Grice S, Beutler J, McKee T, McMahon J
J Nat Prod
. 2008 Sep;
71(9):1634-6.
PMID: 18763827
Three new galloyl arbutins, hyemalosides A-C (1-3), along with nine known compounds were isolated from the evergreen tree Eugenia hyemalis. The structures of compounds 1-3 were determined by analysis of...
19.
Moulaei T, Botos I, Ziolkowska N, Bokesch H, Krumpe L, McKee T, et al.
Protein Sci
. 2007 Oct;
16(12):2756-60.
PMID: 17965185
The crystal structures of the natural and recombinant antiviral lectin scytovirin (SVN) were solved by single-wavelength anomalous scattering and refined with data extending to 1.3 A and 1.0 A resolution,...
20.
Meragelman T, Willis R, Woldemichael G, Heaton A, Murphy P, Snader K, et al.
J Nat Prod
. 2007 Jun;
70(7):1133-8.
PMID: 17564468
Fractionation of cytotoxic extracts of specimens of a newly described sponge genus, Candidaspongia, has yielded the candidaspongiolides (3), a complex mixture of acyl esters of a macrolide related to tedanolide....