Tatiana V Ilina
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Explore the profile of Tatiana V Ilina including associated specialties, affiliations and a list of published articles.
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13
Citations
41
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Recent Articles
1.
Chagas B, Zhou X, Guerrero M, Ilina T, Ishima R
Protein Sci
. 2024 Jun;
33(7):e5080.
PMID: 38896002
The Gag-Pol polyprotein in human immunodeficiency virus type I (HIV-1) encodes enzymes that are essential for virus replication: protease (PR), reverse transcriptase (RT), and integrase (IN). The mature forms of...
2.
Sun Z, Chu X, Adams C, Ilina T, Guerrero M, Lin G, et al.
Mol Ther Oncolytics
. 2023 Sep;
31:100726.
PMID: 37771390
Mesothelin (MSLN) has been a validated tumor-associated antigen target for several solid tumors for over a decade, making it an attractive option for therapeutic interventions. Novel antibodies with high affinity...
3.
Aryal M, Lin D, Regan K, Du S, Shi H, Alvarado J, et al.
Sci Signal
. 2022 Sep;
15(752):eabn8359.
PMID: 36126115
The Nef protein produced by the viruses HIV-1 and SIV drives efficient viral replication partially by inducing constitutive activation of host cell tyrosine kinases, including members of the Src and...
4.
Xi Z, Ilina T, Guerrero M, Fan L, Sluis-Cremer N, Wang Y, et al.
Protein Sci
. 2022 Apr;
31(5):e4307.
PMID: 35481647
HIV-1 reverse transcriptase (RT) is a heterodimer comprised p66 and p51 subunits (p66/p51). Several single amino acid substitutions in RT, including L289K, decrease p66/p51 dimer affinity, and reduce enzymatic functioning....
5.
Emert-Sedlak L, Moukha-Chafiq O, Shi H, Du S, Alvarado J, Pathak V, et al.
ACS Infect Dis
. 2022 Jan;
8(1):91-105.
PMID: 34985256
HIV-1 Nef is an attractive target for antiretroviral drug discovery because of its role in promoting HIV-1 infectivity, replication, and host immune system avoidance. Here, we applied a screening strategy...
6.
Ilina T, Brosenitsch T, Sluis-Cremer N, Ishima R
Enzymes
. 2021 Dec;
50:227-247.
PMID: 34861939
All retroviruses encode the enzyme, reverse transcriptase (RT), which is involved in the conversion of the single-stranded viral RNA genome into double-stranded DNA. RT is a multifunctional enzyme and exhibits...
7.
Cilento M, Reeve A, Michailidis E, Ilina T, Nagy E, Mitsuya H, et al.
Antimicrob Agents Chemother
. 2021 Sep;
65(12):e0116721.
PMID: 34516245
4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA, MK-8591, islatravir) is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) with exceptional potency against wild-type (WT) and drug-resistant HIV-1 in phase III clinical trials. EFdA resistance is not...
8.
Xi Z, Liu X, Lin R, Persons J, Ilina T, Li W, et al.
Protein Sci
. 2021 Jun;
30(9):1895-1903.
PMID: 34107549
Among the immunoglobulin domains, the CH2 domain has the lowest thermal stability, which also depends on amino acid sequence and buffer conditions. To further identify factors that influence CH2 folding...
9.
Ilina T, Xi Z, Brosenitsch T, Sluis-Cremer N, Ishima R
Int J Mol Sci
. 2020 Dec;
21(24).
PMID: 33333923
NMR studies of large proteins, over 100 kDa, in solution are technically challenging and, therefore, of considerable interest in the biophysics field. The challenge arises because the molecular tumbling of...
10.
Khan S, Persons J, Guerrero M, Ilina T, Oda M, Ishima R
Protein Sci
. 2020 Dec;
30(3):571-582.
PMID: 33314454
A clinically-relevant, drug-resistant mutant of HIV-1 protease (PR), termed Flap+ and containing L10I, G48V, I54V and V82A mutations, is known to produce significant changes in the entropy and enthalpy balance...