Retroviral RNase H: Structure, Mechanism, and Inhibition

Overview

Journal Enzymes

Specialties Biochemistry
Molecular Biology

Date 2021 Dec 4

PMID 34861939

Citations 4

Authors

Tatiana V Ilina

Teresa Brosenitsch

Nicolas Sluis-Cremer

Rieko Ishima

Affiliations

Soon will be listed here.

Abstract

All retroviruses encode the enzyme, reverse transcriptase (RT), which is involved in the conversion of the single-stranded viral RNA genome into double-stranded DNA. RT is a multifunctional enzyme and exhibits DNA polymerase and ribonuclease H (RNH) activities, both of which are essential to the reverse-transcription process. Despite the successful development of polymerase-targeting antiviral drugs over the last three decades, no bona fide inhibitor against the RNH activity of HIV-1 RT has progressed to clinical evaluation. In this review article, we describe the retroviral RNH function and inhibition, with primary consideration of the structural aspects of inhibition.

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