Stefan G Sarafianos
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Explore the profile of Stefan G Sarafianos including associated specialties, affiliations and a list of published articles.
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181
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4342
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Recent Articles
1.
McFadden W, Faerch M, Kirby K, Dick R, Torbett B, Sarafianos S
Trends Mol Med
. 2025 Feb;
PMID: 40021388
Antiretroviral therapy (ART) impairs viral replication in people living with HIV (PLWH) by suppressing infection or spread. However, not all treatment strategies apply to preventive applications like pre-exposure prophylaxis (PrEP)...
2.
Lin Y, Jones B, Ridgeway M, Panczyk E, Somogyi A, Kaplan D, et al.
Anal Chem
. 2025 Feb;
97(7):3827-3835.
PMID: 39957060
Native mass spectrometry (nMS) is an increasingly popular technique for studying intact protein quaternary structure. When coupled with ion mobility, which separates ions based on their size, charge, and shape,...
3.
Disruption of LEDGF/p75-directed integration derepresses antisense transcription of the HIV-1 genome
Tedbury P, Mahboubi D, Puray-Chavez M, Shah R, Ukah O, Wahoski C, et al.
bioRxiv
. 2024 Dec;
PMID: 39677798
Disruption of HIV-1 Integrase (IN) interactions with the host-factor Lens Epithelium-Derived Growth Factor (LEDGF)/p75 leads to decreased, random integration, increased latent infection, and described here, accumulation of HIV-1 antisense RNA...
4.
Neilsen G, Mathew A, Castro J, McFadden W, Wen X, Ong Y, et al.
mBio
. 2024 Nov;
15(12):e0336823.
PMID: 39530689
The coronavirus-induced disease 19 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections, has had a devastating impact on millions of lives globally, with severe mortality rates and...
5.
M Ravichandran S, McFadden W, A Snyder A, Sarafianos S
Glob Health Med
. 2024 Nov;
6(5):285-294.
PMID: 39483451
Human immunodeficiency virus (HIV) impacts millions of individuals worldwide, and well over 2/3 of those living with HIV are accessing antiviral therapies that are successfully repressing viral replication. Most often,...
6.
Li D, Donadu M, Shue T, Dangas G, Athanasiadis A, Lan S, et al.
Pharmaceuticals (Basel)
. 2024 Sep;
17(9).
PMID: 39338351
Human coronaviruses are a continuous threat to the human population and have limited antiviral treatments, and the recent COVID-19 pandemic sparked interest in finding new antiviral strategies, such as natural...
7.
Jang S, Bedwell G, Singh S, Yu H, Arnarson B, Singh P, et al.
Nucleic Acids Res
. 2024 Sep;
52(18):11060-11082.
PMID: 39258548
HIV-1 integration favors nuclear speckle (NS)-proximal chromatin and viral infection induces the formation of capsid-dependent CPSF6 condensates that colocalize with nuclear speckles (NSs). Although CPSF6 displays liquid-liquid phase separation (LLPS)...
8.
Akaberi D, Pourghasemi Lati M, Krambrich J, Berger J, Neilsen G, Strandback E, et al.
Antimicrob Agents Chemother
. 2024 Aug;
68(10):e0090924.
PMID: 39194208
screening of large compound libraries with automated high-throughput screening is expensive and time-consuming and requires dedicated infrastructures. Conversely, the selection of DNA-encoded chemical libraries (DECLs) can be rapidly performed with...
9.
Akther T, McFadden W, Zhang H, Kirby K, Sarafianos S, Wang Z
Int J Mol Sci
. 2024 Apr;
25(7).
PMID: 38612545
HIV-1 capsid protein (CA) is the molecular target of the recently FDA-approved long acting injectable (LAI) drug lenacapavir (GS-6207). The quick emergence of CA mutations resistant to GS-6207 necessitates the...
10.
Bruce A, Adebomi V, Czabala P, Palmer J, McFadden W, Lorson Z, et al.
Angew Chem Int Ed Engl
. 2024 Mar;
63(21):e202320045.
PMID: 38529717
In the realm of high-throughput screening (HTS), macrocyclic peptide libraries traditionally necessitate decoding tags, essential for both library synthesis and identifying hit peptide sequences post-screening. Our innovation introduces a tag-free...