Nicolas Sluis-Cremer
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Explore the profile of Nicolas Sluis-Cremer including associated specialties, affiliations and a list of published articles.
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104
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1718
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Recent Articles
1.
Li Y, Soto-Ramirez Z, Roscher J, Medvec T, Alaoui-El-Azher M, Piazza P, et al.
medRxiv
. 2025 Feb;
PMID: 39974095
Background: HIV-1 is associated with accelerated aging. The senescence-associated secretory phenotype (SASP) includes biological and cytokine profiles that induce cellular senescence and inflammaging. In this study, we leveraged the Multicenter...
2.
Gerberick A, Rinaldo C, Sluis-Cremer N
Med Res Arch
. 2024 Dec;
11(7.1).
PMID: 39634038
Despite potent antiretroviral therapy, an HIV-1 reservoir persists that represents a major barrier to a cure. Understanding the mechanisms by which the HIV-1 reservoir is established and maintained is critical...
3.
Vergara S, Zhou X, Santiago U, Alaoui-El-Azher M, Conway J, Sluis-Cremer N, et al.
Nat Commun
. 2024 Dec;
15(1):10553.
PMID: 39632888
Reverse transcription of the retroviral RNA genome into DNA is an integral step during HIV-1 replication. Despite a wealth of structural information on reverse transcriptase (RT), we lack insight into...
4.
Jennings J, Bracey H, Hong J, Nguyen D, Dasgupta R, Rivera A, et al.
PLoS Pathog
. 2024 Sep;
20(9):e1011810.
PMID: 39226318
The viral capsid performs critical functions during HIV-1 infection and is a validated target for antiviral therapy. Previous studies have established that the proper structure and stability of the capsid...
5.
Rivera A, Donald H, Alaoui-El-Azher M, Skoko J, Lazo J, Parniak M, et al.
Biomolecules
. 2024 Jul;
14(7).
PMID: 39062532
The ribonuclease H (RNase H) active site of HIV-1 reverse transcriptase (RT) is the only viral enzyme not targeted by approved antiretroviral drugs. Using a fluorescence-based in vitro assay, we...
6.
Vergara S, Zhou X, Santiago U, Conway J, Sluis-Cremer N, Calero G
bioRxiv
. 2024 Jan;
PMID: 38187617
Reverse transcription of the retroviral single-stranded RNA into double-stranded DNA is an integral step during HIV-1 replication, and reverse transcriptase (RT) is a primary target for antiviral therapy. Despite a...
7.
Okpaise D, Sluis-Cremer N, Rappocciolo G, Rinaldo C
Viruses
. 2023 Dec;
15(12).
PMID: 38140588
Antiretroviral therapy (ART) provides an effective method for managing HIV-1 infection and preventing the onset of AIDS; however, it is ineffective against the reservoir of latent HIV-1 that persists predominantly...
8.
Tuttle D, Castanha P, Nasser A, Wilkins M, Galarza T, Alaoui-El-Azher M, et al.
J Infect Dis
. 2023 Nov;
229(4):1147-1157.
PMID: 38035792
Background: Immune dysregulation in people with human immunodeficiency virus-1 (PWH) persists despite potent antiretroviral therapy and, consequently, PWH tend to have lower immune responses to licensed vaccines. However, limited information...
9.
Jennings J, Bracey H, Nguyen D, Dasgupta R, Rivera A, Sluis-Cremer N, et al.
bioRxiv
. 2023 Nov;
PMID: 37986899
The viral capsid performs critical functions during HIV-1 infection and is a validated target for antiviral therapy. Previous studies have established that the proper structure and stability of the capsid...
10.
Sluis-Cremer N, Traverso Aviles E, Gonzalez O, Rios-Velazquez C, Ortiz-Bermudez P, Ross R, et al.
J Acquir Immune Defic Syndr
. 2023 Sep;
94(2S):S122-S126.
PMID: 37707859
Background: Case Western Reserve University (CWRU)/University Hospitals Cleveland Medical Center in Cleveland, OH, and the University of Pittsburgh (Pitt) in Pittsburgh, PA, forged a strategic alliance to form the Rustbelt...