Zhaoyong Xi
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Explore the profile of Zhaoyong Xi including associated specialties, affiliations and a list of published articles.
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24
Citations
283
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Recent Articles
1.
Xi Z, Ilina T, Guerrero M, Fan L, Sluis-Cremer N, Wang Y, et al.
Protein Sci
. 2022 Apr;
31(5):e4307.
PMID: 35481647
HIV-1 reverse transcriptase (RT) is a heterodimer comprised p66 and p51 subunits (p66/p51). Several single amino acid substitutions in RT, including L289K, decrease p66/p51 dimer affinity, and reduce enzymatic functioning....
2.
Xi Z, Liu X, Lin R, Persons J, Ilina T, Li W, et al.
Protein Sci
. 2021 Jun;
30(9):1895-1903.
PMID: 34107549
Among the immunoglobulin domains, the CH2 domain has the lowest thermal stability, which also depends on amino acid sequence and buffer conditions. To further identify factors that influence CH2 folding...
3.
Ilina T, Xi Z, Brosenitsch T, Sluis-Cremer N, Ishima R
Int J Mol Sci
. 2020 Dec;
21(24).
PMID: 33333923
NMR studies of large proteins, over 100 kDa, in solution are technically challenging and, therefore, of considerable interest in the biophysics field. The challenge arises because the molecular tumbling of...
4.
Xi Z, Wang Z, Sarafianos S, Myshakina N, Ishima R
ACS Infect Dis
. 2019 Oct;
5(11):1963-1974.
PMID: 31577424
The ribonuclease H (RNH) activity of HIV-1 reverse transcriptase (RT) is essential for viral replication and can be a target for drug development. Yet, no RNH inhibitor to date has...
5.
Slack R, Ilina T, Xi Z, Giacobbi N, Kawai G, Parniak M, et al.
Structure
. 2019 Sep;
27(10):1581-1593.e3.
PMID: 31471129
HIV-1 reverse transcriptase (RT) is translated as part of the Gag-Pol polyprotein that is proteolytically processed by HIV-1 protease (PR) to finally become a mature heterodimer, composed of a p66...
6.
Oda M, Xi Z, Inaba S, Slack R, Ishima R
J Therm Anal Calorim
. 2019 Mar;
135(5):2647-2653.
PMID: 30853849
Metal-protein interactions are not necessarily tight in many transient biological processes, such as cellular signaling, enzyme regulation, and molecular recognition. Here, we analyzed the binding thermodynamics and characterized the structural...
7.
Cheng L, Li C, Xi Z, Wei K, Yuan S, Arnesano F, et al.
Metallomics
. 2019 Jan;
11(3):556-564.
PMID: 30672544
Cisplatin is an anticancer drug widely used in clinics; it induces the apoptosis of cancer cells by targeting DNA. However, its interaction with proteins has been found to be crucial...
8.
Sharaf N, Xi Z, Ishima R, Gronenborn A
Proteins
. 2017 Sep;
85(12):2191-2197.
PMID: 28905420
Non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase (RT), NNRTIs, which bind to the p66/p51 heterodimeric RT, also interact with the p66/p66 homodimer, whose structure is unknown. F...
9.
Kirby K, Myshakina N, Christen M, Chen Y, Schmidt H, Huber A, et al.
Antimicrob Agents Chemother
. 2017 Aug;
61(10).
PMID: 28760905
The RNase H (RNH) function of HIV-1 reverse transcriptase (RT) plays an essential part in the viral life cycle. We report the characterization of YLC2-155, a 2-hydroxyisoquinoline-1,3-dione (HID)-based active-site RNH...
10.
Yuan S, Chen S, Xi Z, Liu Y
Metallomics
. 2017 Aug;
9(8):1169-1175.
PMID: 28759062
The cellular copper level is strictly regulated since excessive copper is harmful to cells. It has been proposed that the expression of copper transport protein hCtr1 is transcriptionally regulated by...