Suvi Annala
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Explore the profile of Suvi Annala including associated specialties, affiliations and a list of published articles.
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10
Citations
365
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Recent Articles
1.
Kuppers J, Benkel T, Annala S, Kimura K, Reinelt L, Fleischmann B, et al.
Chemistry
. 2020 May;
26(55):12615-12623.
PMID: 32428383
The 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine derivative BIM-46174 and its dimeric form BIM-46187 (1) are heterocyclized dipeptides that belong to the very few cell-permeable compounds known to preferentially silence Gα proteins. To explore the...
2.
Kuppers J, Benkel T, Annala S, Schnakenburg G, Kostenis E, Gutschow M
Medchemcomm
. 2020 Mar;
10(10):1838-1843.
PMID: 32180917
The 5,6,7,8-tetrahydroimidazo[1,2-]pyrazine derivative BIM-46174 has received attention as Gα inhibitor. We conducted structural reductions to monocyclic and bicyclic substructures to explore the chemical space of BIM fragments and to gain...
3.
Kostenis E, Pfeil E, Annala S
J Biol Chem
. 2020 Mar;
295(16):5206-5215.
PMID: 32122969
Heterotrimeric G proteins are the core upstream elements that transduce and amplify the cellular signals from G protein-coupled receptors (GPCRs) to intracellular effectors. GPCRs are the largest family of membrane...
4.
Annala S, Feng X, Shridhar N, Eryilmaz F, Patt J, Yang J, et al.
Sci Signal
. 2019 Mar;
12(573).
PMID: 30890659
Somatic gain-of-function mutations of and , which encode α subunits of heterotrimeric Gα proteins, occur in about 85% of cases of uveal melanoma (UM), the most common cancer of the...
5.
Malfacini D, Patt J, Annala S, Harpsoe K, Eryilmaz F, Reher R, et al.
J Biol Chem
. 2019 Feb;
294(15):5747-5758.
PMID: 30745359
Transmembrane signals initiated by a range of extracellular stimuli converge on members of the Gq family of heterotrimeric G proteins, which relay these signals in target cells. Gq family G...
6.
Reher R, Kuschak M, Heycke N, Annala S, Kehraus S, Dai H, et al.
J Nat Prod
. 2018 Jun;
81(7):1628-1635.
PMID: 29943987
The cyclic depsipeptide FR900359 (FR), isolated from the traditional Chinese medicine plant Ardisia crenata, is a potent Gq protein inhibitor and thus a valuable tool to study Gq-mediated signaling of...
7.
Reher R, Kuhl T, Annala S, Benkel T, Kaufmann D, Nubbemeyer B, et al.
ChemMedChem
. 2018 Jun;
13(16):1634-1643.
PMID: 29873888
Direct targeting of intracellular Gα subunits of G protein-coupled receptors by chemical tools is a challenging task in current pharmacological studies and in the development of novel therapeutic approaches. In...
8.
Matthey M, Roberts R, Seidinger A, Simon A, Schroder R, Kuschak M, et al.
Sci Transl Med
. 2017 Sep;
9(407).
PMID: 28904224
Obstructive lung diseases are common causes of disability and death worldwide. A hallmark feature is aberrant activation of G protein-dependent signaling cascades. Currently, drugs targeting single G protein (heterotrimeric guanine...
9.
Schrage R, Schmitz A, Gaffal E, Annala S, Kehraus S, Wenzel D, et al.
Nat Commun
. 2015 Dec;
6:10156.
PMID: 26658454
Despite the discovery of heterotrimeric αβγ G proteins ∼25 years ago, their selective perturbation by cell-permeable inhibitors remains a fundamental challenge. Here we report that the plant-derived depsipeptide FR900359 (FR)...
10.
Keller K, Maass M, Dizayee S, Leiss V, Annala S, Koth J, et al.
Cardiovasc Res
. 2015 Oct;
108(3):348-56.
PMID: 26464333
Aims: Inhibitory G (Gi) proteins have been proposed to be cardioprotective. We investigated effects of Gαi2 knockout on cardiac function and survival in a murine heart failure model of cardiac...