Stefan Kehraus
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Explore the profile of Stefan Kehraus including associated specialties, affiliations and a list of published articles.
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97
Citations
1325
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Recent Articles
1.
Becker T, Heitkotter J, Krome A, Schiefer A, Pfarr K, Ehrens A, et al.
Pharmaceutics
. 2024 Mar;
16(3).
PMID: 38543280
Toxicological studies are a part of the drug development process and the preclinical stages, for which suitable vehicles ensuring easy and safe administration are crucial. However, poor aqueous solubility of...
2.
Hanke W, Alenfelder J, Liu J, Gutbrod P, Kehraus S, Crusemann M, et al.
J Chem Ecol
. 2023 Jul;
49(9-10):549-569.
PMID: 37453001
The cyclic depsipeptide FR900359 (FR) is derived from the soil bacterium Chromobacterium vaccinii and known to bind G proteins of mammals and insects, thereby abolishing the signal transduction of their...
3.
Santarcangelo A, Weber F, Kehraus S, Dickschat J, Schieber A
Food Chem
. 2023 Jun;
425:136473.
PMID: 37295212
In view of the poor acceptance of synthetic food colorants by consumers, there is intense interest in novel natural compounds, preferably from plant-derived sources. We oxidized chlorogenic acid using NaIO...
4.
Voss J, Crusemann M, Bartling C, Kehraus S, Inoue A, Konig G, et al.
iScience
. 2023 Apr;
26(4):106492.
PMID: 37091255
The macrocyclic depsipeptides YM-254890 (YM) and FR900359 (FR) are potent inhibitors of Gα proteins. They are important pharmacological tools and have potential as therapeutic drugs. The hydrogenated, tritium-labeled YM and...
5.
Rox K, Becker T, Schiefer A, Grosse M, Ehrens A, Jansen R, et al.
Pharmaceutics
. 2023 Jan;
15(1).
PMID: 36678760
Methicillin-resistant Staphylococcus aureus (MRSA) is a World Health Organization’s high priority pathogen organism, with an estimated > 100,000 deaths worldwide in 2019. Thus, there is an unmet medical need for...
6.
Voss J, Al-Hroub H, Gedschold R, Dietrich J, Gaffal E, Toma M, et al.
Pharmaceutics
. 2023 Jan;
15(1).
PMID: 36678686
G protein-coupled receptors (GPCRs) transfer extracellular signals across cell membranes by activating intracellular heterotrimeric G proteins. Several studies suggested G proteins as novel drug targets for the treatment of complex...
7.
Becker T, Krome A, Vahdati S, Schiefer A, Pfarr K, Ehrens A, et al.
Pharmaceutics
. 2022 Aug;
14(8).
PMID: 36015283
In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as...
8.
The RNA Polymerase Inhibitor Corallopyronin A Has a Lower Frequency of Resistance Than Rifampicin in
Balansky J, Pfarr K, Szekat C, Kehraus S, Aden T, Grosse M, et al.
Antibiotics (Basel)
. 2022 Jul;
11(7).
PMID: 35884174
Corallopyronin A (CorA) is active against Gram-positive bacteria and targets the switch region of RNA polymerase. Because of the high frequency of mutation (FoM) leading to rifampicin resistance, we determined...
9.
Krome A, Becker T, Kehraus S, Schiefer A, Gutschow M, Chaverra-Munoz L, et al.
Nat Prod Rep
. 2022 Jun;
39(9):1705-1720.
PMID: 35730490
Covering: August 1984 up to January 2022Worldwide, increasing morbidity and mortality due to antibiotic-resistant microbial infections has been observed. Therefore, better prevention and control of infectious diseases, as well as...
10.
Voss J, Nagel J, Rafehi M, Guixa-Gonzalez R, Malfacini D, Patt J, et al.
Pharmacol Res
. 2021 Sep;
173:105880.
PMID: 34506902
G proteins represent intracellular switches that transduce signals relayed from G protein-coupled receptors. The structurally related macrocyclic depsipeptides FR900359 (FR) and YM-254890 (YM) are potent, selective inhibitors of the Gα...