Raphael Reher
Overview
Explore the profile of Raphael Reher including associated specialties, affiliations and a list of published articles.
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26
Citations
923
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Recent Articles
1.
Alexander K, Naman C, Iwasaki A, Mangoni A, Leao T, Reher R, et al.
J Nat Prod
. 2025 Jan;
88(2):322-335.
PMID: 39879528
A structurally novel metabolite, fatuamide A (), was discovered from a laboratory cultured strain of the marine cyanobacterium sp., collected from Faga'itua Bay, American Samoa. A bioassay-guided approach using NCI-H460...
2.
Zdouc M, Blin K, Louwen N, Navarro J, Loureiro C, Bader C, et al.
Nucleic Acids Res
. 2024 Dec;
53(D1):D678-D690.
PMID: 39657789
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is...
3.
Heidrich L, Brand B, Brackmann S, Schauble J, Aly M, Reher R, et al.
Arch Pharm (Weinheim)
. 2024 Sep;
357(11):e2400517.
PMID: 39279545
Resins have been used as remedies since ancient times and various embalming resins have been identified in recent years. In Europe, Mumia vera aegyptiaca, a resinous substance from ancient Egyptian...
4.
Berger T, Alenfelder J, Steinmuller S, Heimann D, Gohain N, Petras D, et al.
J Nat Prod
. 2024 Feb;
87(4):692-704.
PMID: 38385767
The marine sponge-derived fungus 293 K04 is a prolific producer of specialized metabolites, including certain cyclic tetrapeptides called endolides, which are characterized by the presence of the unusual amino acid...
5.
Stincone P, Naimi A, Saviola A, Reher R, Petras D
Proteomics
. 2023 Nov;
24(12-13):e2200533.
PMID: 37929699
With the emergence of next-generation nucleotide sequencing and mass spectrometry-based proteomics and metabolomics tools, we have comprehensive and scalable methods to analyze the genes, transcripts, proteins, and metabolites of a...
6.
Mullowney M, Duncan K, Elsayed S, Garg N, van der Hooft J, Martin N, et al.
Nat Rev Drug Discov
. 2023 Sep;
22(11):895-916.
PMID: 37697042
Developments in computational omics technologies have provided new means to access the hidden diversity of natural products, unearthing new potential for drug discovery. In parallel, artificial intelligence approaches such as...
7.
Kim H, Zhang C, Reher R, Wang M, Alexander K, Nothias L, et al.
J Cheminform
. 2023 Aug;
15(1):71.
PMID: 37550756
The identification of molecular structure is essential for understanding chemical diversity and for developing drug leads from small molecules. Nevertheless, the structure elucidation of small molecules by Nuclear Magnetic Resonance...
8.
Leao T, Wang M, da Silva R, Gurevich A, Bauermeister A, Gomes P, et al.
PNAS Nexus
. 2023 Jan;
1(5):pgac257.
PMID: 36712343
Microbial specialized metabolites are an important source of and inspiration for many pharmaceuticals, biotechnological products and play key roles in ecological processes. Untargeted metabolomics using liquid chromatography coupled with tandem...
9.
Reher R, Aron A, Fajtova P, Stincone P, Wagner B, Perez-Lorente A, et al.
Nat Commun
. 2022 Aug;
13(1):4619.
PMID: 35941113
The identity and biological activity of most metabolites still remain unknown. A bottleneck in the exploration of metabolite structures and pharmaceutical activities is the compound purification needed for bioactivity assignments...
10.
Taton A, Rohrer S, Diaz B, Reher R, Caraballo Rodriguez A, Pierce M, et al.
ACS Chem Biol
. 2022 Jun;
17(7):1910-1923.
PMID: 35761435
Columbamides are chlorinated acyl amide natural products, several of which exhibit cannabinomimetic activity. These compounds were originally discovered from a culture of the filamentous marine cyanobacterium PNG5-198 collected from the...