Evi Kostenis
Overview
Explore the profile of Evi Kostenis including associated specialties, affiliations and a list of published articles.
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170
Citations
4300
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Recent Articles
1.
Wurnig S, Huber M, Weiler C, Baltrukevich H, Merten N, Stotzel I, et al.
J Med Chem
. 2025 Feb;
68(4):4308-4333.
PMID: 39937529
Intracellular ligands of G protein-coupled receptors (GPCRs) are gaining significant interest in drug discovery. Here, we report the development of the fluorescent ligand Mz437 () targeting the CC chemokine receptor...
2.
Bormann A, Korner M, Dahse A, Glaser M, Irmer J, Lede V, et al.
Cell Rep
. 2024 Dec;
44(1):115078.
PMID: 39705141
Adhesion G protein-coupled receptors (aGPCRs) are expressed in all organs and are involved in various mechanobiological processes. They are heavily alternatively spliced, forecasting an extraordinary molecular structural diversity. Here, we...
3.
Holze J, Lauber F, Soler S, Kostenis E, Weindl G
Nat Commun
. 2024 Nov;
15(1):9554.
PMID: 39532846
The discovery of Toll-like receptors (TLRs) represented a significant breakthrough that paved the way for the study of host-pathogen interactions in innate immunity. However, there are still major gaps in...
4.
Boshta N, Lewash M, Kose M, Namasivayam V, Sarkar S, Voss J, et al.
J Med Chem
. 2024 Nov;
67(21):19365-19394.
PMID: 39484825
The G protein-coupled receptor 17 (GPR17) is an orphan receptor involved in inflammatory diseases. GPR17 antagonists have been proposed for the treatment of multiple sclerosis due to their potential to...
5.
Brands J, Bravo S, Jurgenliemke L, Gratz L, Schihada H, Frechen F, et al.
Nat Commun
. 2024 Sep;
15(1):7684.
PMID: 39227390
A long-held tenet in inositol-lipid signaling is that cleavage of membrane phosphoinositides by phospholipase Cβ (PLCβ) isozymes to increase cytosolic Ca in living cells is exclusive to Gq- and Gi-sensitive...
6.
Kostenis E, Jurgenliemke L, Alenfelder J
Signal Transduct Target Ther
. 2024 Jul;
9(1):188.
PMID: 39013896
No abstract available.
7.
Seidinger A, Roberts R, Bai Y, Muller M, Pfeil E, Matthey M, et al.
EMBO Mol Med
. 2024 Jul;
16(8):1930-1956.
PMID: 38977926
Pulmonary arterial hypertension (PAH) is a life-threatening disease with limited survival. Herein, we propose the pharmacological inhibition of Gq proteins as a novel concept to counteract pulmonary vasoconstriction and proliferation/migration...
8.
Matthees E, Filor J, Jaiswal N, Reichel M, Youssef N, DUonnolo G, et al.
Commun Biol
. 2024 Jul;
7(1):802.
PMID: 38956302
G protein-coupled receptors (GPCRs) are mainly regulated by GPCR kinase (GRK) phosphorylation and subsequent β-arrestin recruitment. The ubiquitously expressed GRKs are classified into cytosolic GRK2/3 and membrane-tethered GRK5/6 subfamilies. GRK2/3...
9.
Huber M, Wurnig S, Moumbock A, Toy L, Kostenis E, Bartolome A, et al.
ChemMedChem
. 2024 Jun;
19(20):e202400284.
PMID: 38932712
A conserved intracellular allosteric binding site (IABS) was recently identified at several G protein-coupled receptors (GPCRs). This target site allows the binding of allosteric modulators and enables a new mode...
10.
Berger T, Alenfelder J, Steinmuller S, Heimann D, Gohain N, Petras D, et al.
J Nat Prod
. 2024 Feb;
87(4):692-704.
PMID: 38385767
The marine sponge-derived fungus 293 K04 is a prolific producer of specialized metabolites, including certain cyclic tetrapeptides called endolides, which are characterized by the presence of the unusual amino acid...