Shih-Min A Huang
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Explore the profile of Shih-Min A Huang including associated specialties, affiliations and a list of published articles.
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21
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1882
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Recent Articles
11.
Kirouac D, Schaefer G, Chan J, Merchant M, Orr C, Huang S, et al.
NPJ Syst Biol Appl
. 2017 Sep;
3:25.
PMID: 28879057
[This corrects the article DOI: 10.1038/s41540-017-0016-1.].
12.
Kirouac D, Schaefer G, Chan J, Merchant M, Orr C, Huang S, et al.
NPJ Syst Biol Appl
. 2017 Jun;
3:14.
PMID: 28649441
Approximately 10% of colorectal cancers harbor mutations, which constitutively activate the MAPK signaling pathway. We sought to determine whether ERK inhibitor (GDC-0994)-containing regimens may be of clinical benefit to these...
13.
Wagenaar T, Zabludoff S, Ahn S, Allerson C, Arlt H, Baffa R, et al.
Mol Cancer Res
. 2015 Mar;
13(6):1009-21.
PMID: 25758165
Unlabelled: Hepatocellular carcinoma (HCC) remains a significant clinical challenge with few therapeutic options available to cancer patients. MicroRNA 21-5p (miR-21) has been shown to be upregulated in HCC, but the...
14.
Guo Z, Wang A, Zhang W, Levit M, Gao Q, Barberis C, et al.
Blood
. 2014 Jul;
124(11):1777-89.
PMID: 25006129
Postchemotherapy relapse presents a major unmet medical need in acute myeloid leukemia (AML), where treatment options are limited. CD25 is a leukemic stem cell marker and a conspicuous prognostic marker...
15.
Huang S, Wang A, Greco R, Li Z, Barberis C, Tabart M, et al.
Oncotarget
. 2014 May;
5(10):3362-74.
PMID: 24830942
Inhibitors of JAK2 kinase are emerging as an important treatment modality for myeloproliferative neoplasms (MPN). However, similar to other kinase inhibitors, resistance to JAK2 inhibitors may eventually emerge through a...
16.
Gao Q, Mechin I, Kothari N, Guo Z, Deng G, Haas K, et al.
J Biol Chem
. 2013 Sep;
288(42):30125-30138.
PMID: 24003220
PRP4 kinase is known for its roles in regulating pre-mRNA splicing and beyond. Therefore, a wider spectrum of PRP4 kinase substrates could be expected. The role of PRP4 kinase in...
17.
Xie Y, Avello M, Schirle M, McWhinnie E, Feng Y, Bric-Furlong E, et al.
J Biol Chem
. 2012 Nov;
288(5):2976-85.
PMID: 23184937
Ubiquitination is an essential post-translational modification that mediates diverse cellular functions. SMAD-specific E3 ubiquitin protein ligase 1 (SMURF1) belongs to the Nedd4 family of HECT ubiquitin ligases that directly catalyzes...
18.
Cong F, Cheung A, Huang S
Annu Rev Pharmacol Toxicol
. 2011 Aug;
52:57-78.
PMID: 21819237
Identification of novel, validated targets remains a top priority in modern drug discovery. Chemical genetics represents a powerful approach to the discovery of new targets. Unlike the traditional target-based screen...
19.
Zhang Y, Liu S, Mickanin C, Feng Y, Charlat O, Michaud G, et al.
Nat Cell Biol
. 2011 Apr;
13(5):623-9.
PMID: 21478859
The Wnt/β-catenin signalling pathway plays essential roles in embryonic development and adult tissue homeostasis, and deregulation of this pathway has been linked to cancer. Axin is a concentration-limiting component of...
20.
Huang S, Mishina Y, Liu S, Cheung A, Stegmeier F, Michaud G, et al.
Nature
. 2009 Sep;
461(7264):614-20.
PMID: 19759537
The stability of the Wnt pathway transcription factor beta-catenin is tightly regulated by the multi-subunit destruction complex. Deregulated Wnt pathway activity has been implicated in many cancers, making this pathway...