Annual Review of Pharmacology and Toxicology
Overview
The Annual Review of Pharmacology and Toxicology is a prestigious scholarly journal that provides comprehensive and authoritative reviews on the latest advancements in the fields of pharmacology and toxicology. It covers a wide range of topics including drug discovery, mechanisms of drug action, drug metabolism, toxicology, and drug safety. With its rigorous peer-review process and expert contributions from leading researchers, this journal serves as an invaluable resource for scientists, clinicians, and students interested in understanding the impact of drugs and toxins on human health.
Details
Details
Abbr.
Annu Rev Pharmacol Toxicol
Publisher
Annual Reviews
Start
1976
End
Continuing
Frequency
Annual
p-ISSN
0362-1642
e-ISSN
1545-4304
Country
United States
Language
English
Specialties
Pharmacology
Toxicology
Toxicology
Metrics
Metrics
h-index / Ranks: 508
224
SJR / Ranks: 377
3957
CiteScore / Ranks: 168
28.00
JIF / Ranks: 311
12.5
Recent Articles
1.
Deraison C, Vergnolle N
Annu Rev Pharmacol Toxicol
. 2025 Jan;
65(1):301-314.
PMID: 39847467
Chronic inflammation is a common trait in the pathogenesis of several diseases of the gut, including inflammatory bowel disease and celiac disease. Control of the inflammatory response is crucial in...
2.
Sun Y, Hasbi A, George S
Annu Rev Pharmacol Toxicol
. 2025 Jan;
65(1):215-236.
PMID: 39847466
G protein-coupled receptors (GPCRs) represent the largest family of plasma membrane proteins targeted for therapeutic development. For decades, GPCRs were investigated as monomeric entities during analysis of their pharmacology or...
3.
Empey P, Karnes J, Johnson J
Annu Rev Pharmacol Toxicol
. 2025 Jan;
65(1):111-130.
PMID: 39847465
Pharmacogenetic variation is common and an established driver of response for many drugs. There has been tremendous progress in pharmacogenetics knowledge over the last 30 years and in clinical implementation...
4.
Elenbaas J, Lee P, Patel V, Stitziel N
Annu Rev Pharmacol Toxicol
. 2025 Jan;
65(1):131-148.
PMID: 39847464
Although human genetics has substantial potential to illuminate novel disease pathways and facilitate drug development, identifying causal variants and deciphering their mechanisms remain challenging. We believe these challenges can be...
5.
Shaw A, Steketee J, Bukiya A, Dopico A
Annu Rev Pharmacol Toxicol
. 2025 Jan;
65(1):487-506.
PMID: 39847463
Toluene intoxication constitutes a persistent public health problem worldwide. While most organs can be damaged, the brain is a primary target whether exposure is accidental, occupational, or recreational. Interventions to...
6.
McGonigle P
Annu Rev Pharmacol Toxicol
. 2024 Oct;
65(1):29-46.
PMID: 39389098
Advances in molecular biology and molecular genetics as well as major scientific breakthroughs in immunology and oncology have led to the rapid growth of biologic therapeutics. Their success has resulted...
7.
Wolf M
Annu Rev Pharmacol Toxicol
. 2024 Oct;
65(1):259-280.
PMID: 39374445
The last two decades have witnessed substantial advances in identifying synaptic plasticity responsible for behavioral changes in animal models of substance use disorder. We have learned the most about cocaine-induced...
8.
Do T, Knollmann B
Annu Rev Pharmacol Toxicol
. 2024 Oct;
65(1):443-463.
PMID: 39374431
Ryanodine receptor type 2 (RyR2) is the principal intracellular calcium release channel in the cardiac sarcoplasmic reticulum (SR). Pathological RyR2 hyperactivity generates arrhythmia risk in genetic and structural heart diseases....
9.
Delabays B, De Paoli C, Miller-Nesbitt A, Mooser V
Annu Rev Pharmacol Toxicol
. 2024 Sep;
65(1):149-167.
PMID: 39348854
Genetically driven clinical trial enrichment has been proposed to accelerate and reduce the cost of developing new therapeutics. Usage of this approach has not been comprehensively reviewed. We searched Ovid...
10.
Mosch R, van der Lee M, Guchelaar H, Swen J
Annu Rev Pharmacol Toxicol
. 2024 Sep;
65(1):91-109.
PMID: 39348848
Pharmacogenetics (PGx) aims to optimize drug treatment outcomes by using a patient's genetic profile for individualized drug and dose selection. Currently, reactive and pretherapeutic single-gene PGx tests are increasingly applied...