Anlai Wang
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Explore the profile of Anlai Wang including associated specialties, affiliations and a list of published articles.
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25
Citations
644
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Recent Articles
1.
Nguyen M, Ye H, Xu Y, Truong L, Horsey A, Zhao P, et al.
ACS Med Chem Lett
. 2023 Mar;
14(3):312-318.
PMID: 36923909
Fibroblast growth factor receptors (FGFRs) are transmembrane receptor tyrosine kinases that regulate multiple physiological processes. Aberrant activation of FGFR2 and FGFR3 has been linked to the pathogenesis of many tumor...
2.
Sokolsky A, Vechorkin O, Hummel J, Styduhar E, Wang A, Nguyen M, et al.
ACS Med Chem Lett
. 2023 Jan;
14(1):116-122.
PMID: 36655134
Herein we report the discovery of a novel biaryl amide series as selective inhibitors of hematopoietic protein kinase 1 (HPK1). Structure-activity relationship development, aided by molecular modeling, identified indazole as...
3.
Ye Q, Liu K, Ye H, Pan J, Sokolsky A, Wang A, et al.
ACS Med Chem Lett
. 2023 Jan;
14(1):5-10.
PMID: 36655125
In spite of the great success of immune checkpoint inhibitors in immune-oncology therapy, an urgent need still exists to identify alternative approaches to broaden the scope of therapeutic coverage. Hematopoietic...
4.
Wang A, Song Z, Zheng G, Nicolazzi C, Fromm J, Shehu E, et al.
Mol Cancer Ther
. 2021 Aug;
20(10):1916-1925.
PMID: 34376579
This study reports the pharmacologic effects of isatuximab, a CD38 mAb, on T- and B-cell acute lymphoblastic leukemia (ALL). We analyzed CD38 expression in 50-T-ALL and 50 B-ALL clinical samples,...
5.
Barberis C, Erdman P, Czekaj M, Fire L, Pribish J, Tserlin E, et al.
Bioorg Med Chem Lett
. 2020 Oct;
30(23):127625.
PMID: 33096160
N-substituted azaindoles were discovered as potent pan-PIM inhibitors. Lead optimization, guided by structure and focused on physico-chemical properties allowed us to solve inherent hERG and permeability liabilities, and provided compound...
6.
Zhu C, Song Z, Wang A, Srinivasan S, Yang G, Greco R, et al.
Front Immunol
. 2020 Sep;
11:1771.
PMID: 32922390
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Upon binding to CD38-expressing...
7.
Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III
Barberis C, Pribish J, Tserlin E, Gross A, Czekaj M, Barrague M, et al.
Bioorg Med Chem Lett
. 2018 Dec;
29(3):491-495.
PMID: 30553737
N-substituted azaindoles were discovered as promising pan-PIM inhibitors. Lead optimization is described en route toward the identification of a clinical candidate. Modulation of physico-chemical properties allowed to solve inherent hERG...
8.
Barberis C, Moorcroft N, Pribish J, Tserlin E, Gross A, Czekaj M, et al.
Bioorg Med Chem Lett
. 2017 Sep;
27(20):4735-4740.
PMID: 28927793
N-Substituted azaindoles have been discovered as pan-PIM kinase inhibitors. Initial SAR, early ADME and PK/PD data of a series of compounds is described and led to the identification of promising...
9.
Guo Z, Wang A, Zhang W, Levit M, Gao Q, Barberis C, et al.
Blood
. 2014 Jul;
124(11):1777-89.
PMID: 25006129
Postchemotherapy relapse presents a major unmet medical need in acute myeloid leukemia (AML), where treatment options are limited. CD25 is a leukemic stem cell marker and a conspicuous prognostic marker...
10.
Xue C, Feng H, Cao G, Huang T, Glenn J, Anand R, et al.
ACS Med Chem Lett
. 2014 Jun;
2(6):450-4.
PMID: 24900329
We report the identification of 13 (INCB3284) as a potent human CCR2 (hCCR2) antagonist. INCB3284 exhibited an IC50 of 3.7 nM in antagonism of monocyte chemoattractant protein-1 binding to hCCR2,...