Robert E Hammer
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Explore the profile of Robert E Hammer including associated specialties, affiliations and a list of published articles.
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105
Citations
9843
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Recent Articles
11.
Nagati J, Xu M, Garcia T, Comerford S, Hammer R, Garcia J
PLoS One
. 2019 Nov;
14(11):e0225105.
PMID: 31725783
The response to environmental stresses by eukaryotic organisms includes activation of protective biological mechanisms, orchestrated in part by transcriptional regulators. The tri-member Hypoxia Inducible Factor (HIF) family of DNA-binding transcription...
12.
Acharya A, Berry D, Zhang H, Jiang Y, Jones B, Hammer R, et al.
Genes Dev
. 2019 Sep;
33(19-20):1367-1380.
PMID: 31488578
Fat storage in adult mammals is a highly regulated process that involves the mobilization of adipocyte progenitor cells (APCs) that differentiate to produce new adipocytes. Here we report a role...
13.
Zhou X, Padanad M, Evers B, Smith B, Novaresi N, Suresh S, et al.
Mol Cancer Res
. 2018 Nov;
17(2):594-603.
PMID: 30409919
PROTOCADHERIN 7 (PCDH7), a transmembrane receptor and member of the Cadherin superfamily, is frequently overexpressed in lung adenocarcinoma and is associated with poor clinical outcome. Although PCDH7 was recently shown...
14.
Hunter R, Liu Y, Manjunath H, Acharya A, Jones B, Zhang H, et al.
Genes Dev
. 2018 Jun;
32(13-14):903-908.
PMID: 29950491
Loss of function of the DIS3L2 exoribonuclease is associated with Wilms tumor and the Perlman congenital overgrowth syndrome. LIN28, a Wilms tumor oncoprotein, triggers the DIS3L2-mediated degradation of the precursor...
15.
Linden A, Li S, Choi H, Fang F, Fukasawa M, Uyeda K, et al.
J Lipid Res
. 2018 Jan;
59(3):475-487.
PMID: 29335275
Lipogenesis in liver is highest in the postprandial state; insulin activates SREBP-1c, which transcriptionally activates genes involved in FA synthesis, whereas glucose activates carbohydrate-responsive element-binding protein (ChREBP), which activates both...
16.
Xian X, Ding Y, Dieckmann M, Zhou L, Plattner F, Liu M, et al.
Elife
. 2017 Nov;
6.
PMID: 29144234
Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional cell surface receptor with diverse physiological roles, ranging from cellular uptake of lipoproteins and other cargo by endocytosis to sensor of...
17.
Gu Y, Cohn S, Christie A, McKenzie T, Wolff N, Do Q, et al.
Cancer Discov
. 2017 May;
7(8):900-917.
PMID: 28473526
Clear cell renal cell carcinoma (ccRCC) is characterized by and mutations, which are associated with tumors of different grade and prognosis. However, whether and loss causes ccRCC and determines tumor...
18.
Pritt S, Hammer R
Comp Med
. 2017 Apr;
67(2):101-105.
PMID: 28381309
Reproducibility in animal studies has been defined as the ability of a result to be replicated through independent experiments within the same or among different laboratories. Over the past few...
19.
Rong S, Cortes V, Rashid S, Anderson N, McDonald J, Liang G, et al.
Elife
. 2017 Mar;
6.
PMID: 28244871
The synthesis of cholesterol and fatty acids (FA) in the liver is independently regulated by SREBP-2 and SREBP-1c, respectively. Here, we genetically deleted from hepatocytes and confirmed that SREBP-2 regulates...
20.
Barnea E, Melamed Kadosh D, Haimovich Y, Satumtira N, Dorris M, Nguyen M, et al.
Mol Cell Proteomics
. 2017 Feb;
16(4):642-662.
PMID: 28188227
HLA-B27 is a class I major histocompatibility (MHC-I) allele that confers susceptibility to the rheumatic disease ankylosing spondylitis (AS) by an unknown mechanism. ERAP1 is an aminopeptidase that trims peptides...