S Clay Williams
Overview
Explore the profile of S Clay Williams including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
1580
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Recent Articles
1.
Motoike T, Long J, Tanaka H, Sinton C, Skach A, Williams S, et al.
Proc Natl Acad Sci U S A
. 2016 May;
113(21):6023-8.
PMID: 27140610
Neuropeptide B (NPB) and neuropeptide W (NPW) are endogenous neuropeptide ligands for the G protein-coupled receptors NPBWR1 and NPBWR2. Here we report that the majority of NPW neurons in the...
2.
Funato H, Sato M, Sinton C, Gautron L, Williams S, Skach A, et al.
Proc Natl Acad Sci U S A
. 2010 Oct;
107(42):18155-60.
PMID: 20921407
Sleep and wakefulness are regulated primarily by inhibitory interactions between the hypothalamus and brainstem. The expression of the states of rapid eye movement (REM) sleep and non-REM (NREM) sleep also...
3.
Kisanuki Y, Emoto N, Ohuchi T, Widyantoro B, Yagi K, Nakayama K, et al.
Hypertension
. 2010 Jun;
56(1):121-8.
PMID: 20516397
Endothelin (ET) 1 is a potent vasoconstrictor peptide produced by vascular endothelial cells and implicated in various pathophysiologic states involving abnormal vascular tone. Homozygous ET-1 null mice have craniofacial and...
4.
Funato H, Tsai A, Willie J, Kisanuki Y, Williams S, Sakurai T, et al.
Cell Metab
. 2009 Jan;
9(1):64-76.
PMID: 19117547
The hypothalamic orexin neuropeptide acutely promotes appetite, yet orexin deficiency in humans and mice is associated with obesity. Prolonged effects of increased orexin signaling upon energy homeostasis have not been...
5.
Samuel B, Shaito A, Motoike T, Rey F, Backhed F, Manchester J, et al.
Proc Natl Acad Sci U S A
. 2008 Oct;
105(43):16767-72.
PMID: 18931303
The distal human intestine harbors trillions of microbes that allow us to extract calories from otherwise indigestible dietary polysaccharides. The products of polysaccharide fermentation include short-chain fatty acids that are...
6.
Mieda M, Williams S, Richardson J, Tanaka K, Yanagisawa M
Proc Natl Acad Sci U S A
. 2006 Aug;
103(32):12150-5.
PMID: 16880388
Temporal restriction of feeding can phase-shift behavioral and physiological circadian rhythms in mammals. These changes in biological rhythms are postulated to be brought about by a food-entrainable oscillator (FEO) that...
7.
Kitamura Y, Tanaka H, Motoike T, Ishii M, Williams S, Yanagisawa M, et al.
Brain Res
. 2006 May;
1093(1):123-34.
PMID: 16697979
Neuropeptide W (NPW) is a recently identified neuropeptide that binds to G-protein-coupled receptor (GPR) 7, which is highly expressed in several discrete regions of the rodent brain including the central...
8.
Takayasu S, Sakurai T, Iwasaki S, Teranishi H, Yamanaka A, Williams S, et al.
Proc Natl Acad Sci U S A
. 2006 May;
103(19):7438-43.
PMID: 16648250
Here, we report the isolation and characterization of an endogenous peptide ligand of GPR103 from rat brains. The purified peptide was found to be the 43-residue RF-amide peptide QRFP. We...
9.
Kelly M, Beuckmann C, Williams S, Sinton C, Motoike T, Richardson J, et al.
Proc Natl Acad Sci U S A
. 2005 Jun;
102(28):9942-7.
PMID: 15983370
Neuropeptide B (NPB) and neuropeptide W (NPW) have been recently identified as ligands for the G protein-coupled receptor (GPR) 7 and GPR8. The precise in vivo role of this neuropeptide-receptor...
10.
Ohkita M, Wang Y, Nguyen N, Tsai Y, Williams S, Wiseman R, et al.
Hypertension
. 2005 Apr;
45(5):940-6.
PMID: 15809364
Endothelin-B receptor (ET(B))-deficient rats have low-renin, salt-sensitive hypertension. We hypothesized this was caused by an absence of renal ET(B) signaling and performed a series of experiments to examine the effect...