Jay D Horton
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Explore the profile of Jay D Horton including associated specialties, affiliations and a list of published articles.
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92
Citations
14967
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Recent Articles
1.
Elnwasany A, Ewida H, Menendez-Montes I, Mizerska M, Fu X, Kim C, et al.
J Biol Chem
. 2024 May;
300(7):107412.
PMID: 38796064
The heart alters the rate and relative oxidation of fatty acids and glucose based on availability and energetic demand. Insulin plays a crucial role in this process diminishing fatty acid...
2.
Agarwal A, Tunison K, Horton J, Garg A
iScience
. 2024 Apr;
27(4):109517.
PMID: 38623324
Both humans and mice with congenital generalized lipodystrophy due to AGPAT2 deficiency develop diabetes mellitus, insulin resistance, and hepatic steatosis, which have been attributed to the near total loss of...
3.
Deja S, Fletcher J, Kim C, Kucejova B, Fu X, Mizerska M, et al.
Cell Metab
. 2024 Mar;
36(5):1088-1104.e12.
PMID: 38447582
Acetyl-CoA carboxylase (ACC) promotes prandial liver metabolism by producing malonyl-CoA, a substrate for de novo lipogenesis and an inhibitor of CPT-1-mediated fat oxidation. We report that inhibition of ACC also...
4.
Rong S, Xia M, Vale G, Wang S, Kim C, Li S, et al.
Cell Metab
. 2024 Feb;
36(3):617-629.e7.
PMID: 38340721
Diacylglycerol acyltransferase 2 (DGAT2) catalyzes the final step of triglyceride (TG) synthesis. DGAT2 deletion in mice lowers liver TGs, and DGAT2 inhibitors are under investigation for the treatment of fatty...
5.
Agarwal A, Tunison K, Vale G, McDonald J, Li X, Horton J, et al.
iScience
. 2024 Jan;
27(1):108653.
PMID: 38274405
AGPAT2, a critical enzyme involved in the biosynthesis of phospholipids and triacylglycerol (TAG), is highly expressed in adipose tissue (AT). Whether overexpression of AGPAT2 in AT will result in increased...
6.
Hobbs H, Cohen J, Horton J
Circulation
. 2024 Jan;
149(3):171-173.
PMID: 38227713
No abstract available.
7.
Agarwal A, Tunison K, Vale G, McDonald J, Li X, Scherer P, et al.
iScience
. 2023 Sep;
26(10):107806.
PMID: 37752957
Genetic loss of in humans and mice results in congenital generalized lipodystrophy with near-total loss of adipose tissue and predisposition to develop insulin resistance, diabetes mellitus, hepatic steatosis, and hypertriglyceridemia....
8.
Haddad J, Almandoz J, Gomez V, Schulman A, Horton J, Schellinger J, et al.
Obes Surg
. 2023 Jun;
33(8):2434-2442.
PMID: 37338795
Purpose: Obesity is a complex, chronic disease that is strongly associated with complications which cost the US healthcare system billions of dollars per year. Endoscopic sleeve gastroplasty (ESG) has emerged...
9.
Duell P, Welty F, Miller M, Chait A, Hammond G, Ahmad Z, et al.
Arterioscler Thromb Vasc Biol
. 2022 Apr;
42(6):e168-e185.
PMID: 35418240
Nonalcoholic fatty liver disease (NAFLD) is an increasingly common condition that is believed to affect >25% of adults worldwide. Unless specific testing is done to identify NAFLD, the condition is...
10.
Wang S, Zhu Q, Liang G, Franks T, Boucher M, Bence K, et al.
J Clin Invest
. 2022 Jan;
132(1).
PMID: 34981782
No abstract available.