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Prasanna Vasudevan Iyengar

Explore the profile of Prasanna Vasudevan Iyengar including associated specialties, affiliations and a list of published articles. Areas
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Articles 19
Citations 525
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Recent Articles
1.
Fan C, Wang Q, Kuipers T, Cats D, Iyengar P, Hagenaars S, et al.
EMBO J . 2023 Mar; 42(10):e112806. PMID: 36994542
Epithelial cells acquire mesenchymal phenotypes through epithelial-mesenchymal transition (EMT) during cancer progression. However, how epithelial cells retain their epithelial traits and prevent malignant transformation is not well understood. Here, we...
2.
Iyengar P, Marvin D, Lama D, Tan T, Suriyamurthy S, Xie F, et al.
Mol Cancer Res . 2022 Jun; 20(10):1516-1531. PMID: 35731212
Implications: Our findings identify E3 ubiquitin ligase TRAF4 as a potential therapeutic target or biomarker for bladder cancer progression.
3.
Fan C, Wang Q, van der Zon G, Ren J, Agaser C, Slieker R, et al.
Signal Transduct Target Ther . 2022 Apr; 7(1):126. PMID: 35484112
Ovo-like transcriptional repressor 1 (OVOL1) is a key mediator of epithelial lineage determination and mesenchymal-epithelial transition (MET). The cytokines transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP) control the...
4.
Sinha A, Iyengar P, Ten Dijke P
Int J Mol Sci . 2021 Jan; 22(2). PMID: 33418880
Transforming growth factor β (TGFβ) is a secreted growth and differentiation factor that influences vital cellular processes like proliferation, adhesion, motility, and apoptosis. Regulation of the TGFβ signaling pathway is...
5.
Jaynes P, Iyengar P, Lui S, Tan T, Vasilevski N, Wright S, et al.
Sci Rep . 2020 Sep; 10(1):15725. PMID: 32973272
Systematic control of the transforming growth factor-β (TGFβ) pathway is essential to keep the amplitude and the intensity of downstream signalling at appropriate levels. Ubiquitination plays a crucial role in...
6.
Lui S, Iyengar P, Jaynes P, Bin Adam Isa Z, Pang B, Tan T, et al.
EMBO Rep . 2020 Jan; 21(1):e49618. PMID: 31910334
No abstract available.
7.
Lui S, Iyengar P, Jaynes P, Bin Adam Isa Z, Pang B, Tan T, et al.
EMBO Rep . 2019 Dec; 21(1):e47269. PMID: 31858684
No abstract available.
8.
Liu S, Gonzalez-Prieto R, Zhang M, Geurink P, Kooij R, Iyengar P, et al.
Clin Cancer Res . 2019 Dec; 26(6):1460-1473. PMID: 31857432
Purpose: Therapies directed to specific molecular targets are still unmet for patients with triple-negative breast cancer (TNBC). Deubiquitinases (DUB) are emerging drug targets. The identification of highly active DUBs in...
9.
Sim W, Iyengar P, Lama D, Lui S, Ng H, Haviv-Shapira L, et al.
Nat Commun . 2019 Nov; 10(1):5148. PMID: 31704935
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
10.
Sim W, Iyengar P, Lama D, Lui S, Ng H, Haviv-Shapira L, et al.
Nat Commun . 2019 Sep; 10(1):4349. PMID: 31554791
Treatment of muscle-invasive bladder cancer remains a major clinical challenge. Aberrant HGF/c-MET upregulation and activation is frequently observed in bladder cancer correlating with cancer progression and invasion. However, the mechanisms...