Prasanna Vasudevan Iyengar
Overview
Explore the profile of Prasanna Vasudevan Iyengar including associated specialties, affiliations and a list of published articles.
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19
Citations
525
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Recent Articles
11.
Suriyamurthy S, Baker D, Ten Dijke P, Iyengar P
Cancers (Basel)
. 2019 May;
11(5).
PMID: 31137748
The Transforming Growth Factor-β (TGF-β) signaling pathway has a well-documented, context-dependent role in breast cancer development. In normal and premalignant cells, it acts as a tumor suppressor. By contrast, during...
12.
Gomez-Puerto M, Iyengar P, Garcia de Vinuesa A, Ten Dijke P, Sanchez-Duffhues G
J Pathol
. 2018 Sep;
247(1):9-20.
PMID: 30246251
Bone morphogenetic proteins (BMPs) are secreted cytokines that were initially discovered on the basis of their ability to induce bone. Several decades of research have now established that these proteins...
13.
Saei A, Palafox M, Benoukraf T, Kumari N, Jaynes P, Iyengar P, et al.
J Exp Med
. 2018 Jun;
215(7):1913-1928.
PMID: 29880484
RAF kinase inhibitors are clinically active in patients with BRAF (V600E) mutant melanoma. However, rarely do tumors regress completely, with the majority of responses being short-lived. This is partially mediated...
14.
Kumari N, Jaynes P, Saei A, Iyengar P, Charles Richard J, Eichhorn P
Biochim Biophys Acta Rev Cancer
. 2017 Sep;
1868(2):456-483.
PMID: 28923280
The initial experiments performed by Rose, Hershko, and Ciechanover describing the identification of a specific degradation signal in short-lived proteins paved the way to the discovery of the ubiquitin mediated...
15.
Iyengar P
Int J Mol Sci
. 2017 Apr;
18(4).
PMID: 28425962
The transforming growth factor-β (TGF-β) pathway has a tumor suppressor role in normal and premalignant cells but promotes oncogenesis in advanced cancer cells. Components of the pathway are tightly controlled...
16.
Lui S, Iyengar P, Jaynes P, Bin Adam Isa Z, Pang B, Tan T, et al.
EMBO Rep
. 2017 Apr;
18(5):797-808.
PMID: 28381482
The amplitude of transforming growth factor-β (TGF-β) signal is tightly regulated to ensure appropriate physiological responses. As part of negative feedback loop SMAD7, a direct transcriptional target of downstream TGF-β...
17.
Iyengar P, Jaynes P, Rodon L, Lama D, Law K, Lim Y, et al.
Sci Rep
. 2015 Oct;
5:14733.
PMID: 26435193
Ubiquitin modification of the TGF-β pathway components is emerging as a key mechanism of TGF-β pathway regulation. To limit TGF-β responses, TGF-β signaling is regulated through a negative feedback loop...
18.
Zhao B, Ito K, Iyengar P, Hirose S, Nakamura N
Histochem Cell Biol
. 2012 Oct;
139(3):447-60.
PMID: 23104140
Spermatogenesis is a highly complicated metamorphosis process of male germ cells. Recent studies have provided evidence that the ubiquitin-proteasome system plays an important role in sperm head shaping, but the...
19.
Iyengar P, Hirota T, Hirose S, Nakamura N
J Biol Chem
. 2011 Sep;
286(45):39082-90.
PMID: 21937444
Spermiogenesis is a complex and dynamic process of the metamorphosis of spermatids into spermatozoa. There is a great deal that is still unknown regarding the regulatory mechanisms for the formation...