Sarah Kit Leng Lui
Overview
Explore the profile of Sarah Kit Leng Lui including associated specialties, affiliations and a list of published articles.
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10
Citations
149
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Recent Articles
1.
Lai X, Lui S, Lam H, Adachi Y, Sim W, Vasilevski N, et al.
NPJ Precis Oncol
. 2023 Dec;
7(1):136.
PMID: 38102334
Despite the promising antitumor activity of SHP2 inhibitors in RAS-dependent tumours, overall responses have been limited by their narrow therapeutic window. Like with all MAPK pathway inhibitors, this is likely...
2.
Coleman K, Yin Y, Lui S, Keegan S, Fenyo D, Smith D, et al.
Nat Commun
. 2022 Apr;
13(1):1740.
PMID: 35365626
The deubiquitinase USP1 is a critical regulator of genome integrity through the deubiquitylation of Fanconi Anemia proteins and the DNA replication processivity factor, proliferating cell nuclear antigen (PCNA). Uniquely, following...
3.
Lui S, Keegan S, Tonzi P, Kahli M, Chen Y, Chalhoub N, et al.
Nat Protoc
. 2021 Jan;
16(2):1193-1218.
PMID: 33442052
The ability to monitor DNA replication fork directionality at the genome-wide scale is paramount for a greater understanding of how genetic and environmental perturbations can impact replication dynamics in human...
4.
Jaynes P, Iyengar P, Lui S, Tan T, Vasilevski N, Wright S, et al.
Sci Rep
. 2020 Sep;
10(1):15725.
PMID: 32973272
Systematic control of the transforming growth factor-β (TGFβ) pathway is essential to keep the amplitude and the intensity of downstream signalling at appropriate levels. Ubiquitination plays a crucial role in...
5.
Lui S, Iyengar P, Jaynes P, Bin Adam Isa Z, Pang B, Tan T, et al.
EMBO Rep
. 2020 Jan;
21(1):e49618.
PMID: 31910334
No abstract available.
6.
Lui S, Iyengar P, Jaynes P, Bin Adam Isa Z, Pang B, Tan T, et al.
EMBO Rep
. 2019 Dec;
21(1):e47269.
PMID: 31858684
No abstract available.
7.
Sim W, Iyengar P, Lama D, Lui S, Ng H, Haviv-Shapira L, et al.
Nat Commun
. 2019 Nov;
10(1):5148.
PMID: 31704935
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
8.
Sim W, Iyengar P, Lama D, Lui S, Ng H, Haviv-Shapira L, et al.
Nat Commun
. 2019 Sep;
10(1):4349.
PMID: 31554791
Treatment of muscle-invasive bladder cancer remains a major clinical challenge. Aberrant HGF/c-MET upregulation and activation is frequently observed in bladder cancer correlating with cancer progression and invasion. However, the mechanisms...
9.
Teyra J, Singer A, Schmitges F, Jaynes P, Lui S, Polyak M, et al.
Structure
. 2019 Feb;
27(4):590-605.e5.
PMID: 30713027
The multi-domain deubiquitinase USP15 regulates diverse eukaryotic processes and has been implicated in numerous diseases. We developed ubiquitin variants (UbVs) that targeted either the catalytic domain or each of three...
10.
Lui S, Iyengar P, Jaynes P, Bin Adam Isa Z, Pang B, Tan T, et al.
EMBO Rep
. 2017 Apr;
18(5):797-808.
PMID: 28381482
The amplitude of transforming growth factor-β (TGF-β) signal is tightly regulated to ensure appropriate physiological responses. As part of negative feedback loop SMAD7, a direct transcriptional target of downstream TGF-β...