Paul B Rothman
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Explore the profile of Paul B Rothman including associated specialties, affiliations and a list of published articles.
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2486
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Recent Articles
21.
Yang J, Wang J, Chen K, Guo G, Xi R, Rothman P, et al.
Cancer Res
. 2013 Jun;
73(15):4898-908.
PMID: 23749639
Alterations in translation occur in cancer cells, but the precise pathogenic processes and mechanistic underpinnings are not well understood. In this study, we report that interactions between Pim family kinases...
22.
Lu P, Hostager B, Rothman P, Colgan J
Methods Mol Biol
. 2013 Feb;
977:365-83.
PMID: 23436378
Co-repressor proteins function as platforms for the assembly of multi-subunit complexes that mediate transcriptional repression. Common components of such complexes are histone deacetylases, which catalyze the removal of acetyl groups...
23.
Qiu X, Guo G, Chen K, Kashiwada M, Druker B, Rothman P, et al.
Neoplasia
. 2012 Jul;
14(6):547-58.
PMID: 22787435
Suppressors of cytokine signaling 1 and 3 (SOCS-1 and SOCS-3) are inhibitors of the Janus tyrosine kinase (JAK)/signal transducers and activators of transcription (STAT) pathway and function in a negative...
24.
Curtiss M, Gorman J, Businga T, Traver G, Singh M, Meyerholz D, et al.
Eur J Immunol
. 2011 Dec;
42(3):651-61.
PMID: 22144095
T-cell immunoglobulin mucin-1 (Tim-1) is a transmembrane protein postulated to be a key regulator of Th2-type immune responses. This hypothesis is based in part upon genetic studies associating Tim-1 polymorphisms...
25.
Hostager B, Kashiwada M, Colgan J, Rothman P
PLoS One
. 2011 Aug;
6(8):e23061.
PMID: 21829693
CD40 is a cell surface receptor important in the activation of antigen-presenting cells during immune responses. In macrophages and dendritic cells, engagement of CD40 by its ligand CD154 provides signals...
26.
Mostecki J, Cassel S, Klimecki W, Stern D, Knisz J, Iwashita S, et al.
J Immunol
. 2011 Jul;
187(5):2794-802.
PMID: 21795592
SOCS-1 is a critical regulator of multiple signaling pathways, including those activated by cytokines that regulate Ig H chain class switching to IgE. Analysis of mice with mutations in the...
27.
Curtiss M, Hostager B, Stepniak E, Singh M, Manhica N, Knisz J, et al.
Mol Immunol
. 2011 Apr;
48(12-13):1424-31.
PMID: 21513984
The gene encoding T cell immunoglobulin and mucin domain-1 (Tim-1) is linked to atopy and asthma susceptibility in mice and humans. Tim-1 is a transmembrane protein expressed on activated lymphocytes...
28.
Kashiwada M, Cassel S, Colgan J, Rothman P
EMBO J
. 2011 Apr;
30(10):2071-82.
PMID: 21499227
Type 2 T helper (T(H)2) cells are critical for the development of allergic immune responses; however, the molecular mechanism controlling their effector function is still largely unclear. Here, we report...
29.
Kashiwada M, Pham N, Pewe L, Harty J, Rothman P
Blood
. 2011 Apr;
117(23):6193-7.
PMID: 21474667
Antigen presentation by mature dendritic cells (DCs) is the first step for initiating adaptive immune responses. DCs are composed of heterogeneous functional subsets; however, the molecular mechanisms that regulate differentiation...
30.
Lu P, Hankel I, Hostager B, Swartzendruber J, Friedman A, Brenton J, et al.
J Biol Chem
. 2011 Apr;
286(20):18311-9.
PMID: 21454521
Genetic studies involving zebrafish and mice have demonstrated that the protein Gon4l (Gon4-like) is essential for hematopoiesis. These studies also suggested that Gon4l regulates gene expression during hematopoietic development, yet...