Paul B Rothman
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Explore the profile of Paul B Rothman including associated specialties, affiliations and a list of published articles.
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2486
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Recent Articles
31.
Kobayashi T, Matsuoka K, Sheikh S, Elloumi H, Kamada N, Hisamatsu T, et al.
J Immunol
. 2011 Mar;
186(8):4649-55.
PMID: 21383239
Regulation of innate inflammatory responses against the enteric microbiota is essential for the maintenance of intestinal homeostasis. Key participants in innate defenses are macrophages. In these studies, the basic leucine...
32.
Rothman P
Trans Am Clin Climatol Assoc
. 2010 Aug;
121:156-71.
PMID: 20697558
Cytokines are essential modulators of the immune response that underlies the inflammatory component of atopic asthma and other allergic diseases, lnterleukin-4 is an important cytokine for the regulation of allergic...
33.
Hostager B, Fox D, Whitten D, Wilkerson C, Eipper B, Francone V, et al.
PLoS One
. 2010 Jul;
5(6):e11380.
PMID: 20614026
The tumor necrosis factor receptor (TNFR) superfamily mediates signals critical for regulation of the immune system. One family member, CD40, is important for the efficient activation of antibody-producing B cells...
34.
Lu P, Hankel I, Knisz J, Marquardt A, Chiang M, Grosse J, et al.
J Exp Med
. 2010 Jun;
207(7):1359-67.
PMID: 20530203
A recessive mutation named Justy was found that abolishes B lymphopoiesis but does not impair other major aspects of hematopoiesis. Transplantation experiments showed that homozygosity for Justy prevented hematopoietic progenitors...
35.
Berger A, Niki M, Morotti A, Taylor B, Socci N, Viale A, et al.
Nat Genet
. 2010 Feb;
42(3):216-23.
PMID: 20139980
Genome-wide analyses of human lung adenocarcinoma have identified regions of consistent copy-number gain or loss, but in many cases the oncogenes and tumor suppressors presumed to reside in these loci...
36.
Kashiwada M, Levy D, McKeag L, Murray K, Schroder A, Canfield S, et al.
Proc Natl Acad Sci U S A
. 2010 Jan;
107(2):821-6.
PMID: 20080759
IL-4 signaling promotes IgE class switching through STAT6 activation and the induction of Ig germ-line epsilon (GLepsilon) transcription. Previously, we and others identified a transcription factor, Nfil3, as a gene...
37.
Collins M, Tremblay M, Chapman N, Curtiss M, Rothman P, Houtman J
J Leukoc Biol
. 2009 Dec;
87(4):691-701.
PMID: 20028775
The tyrosine kinase Pyk2 is vital for integrating receptor-mediated signals controlling adhesion and motility in neuronal, epithelial, and hematopoietic cell types. In T cells, the stimulation of the TCR and...
38.
Cassel S, Rothman P
Adv Immunol
. 2009 Sep;
103:49-76.
PMID: 19755183
Cytokines are powerful mediators of the immune response that, following initial release by components of the innate system, drive effector functions as well as stimulate the additional arms of the...
39.
Knisz J, Banks A, McKeag L, Metcalfe D, Rothman P, Brown J
Clin Immunol
. 2009 May;
132(2):277-84.
PMID: 19427817
The Suppressor of Cytokine Signaling (SOCS) protein family plays a central role in the negative regulation of cytokine action and has been implicated in the development of atopic diseases. Lack...
40.
Cassel S, Eisenbarth S, Iyer S, Sadler J, Colegio O, Tephly L, et al.
Proc Natl Acad Sci U S A
. 2008 Jun;
105(26):9035-40.
PMID: 18577586
Inhalation of crystalline silica and asbestos is known to cause the progressive pulmonary fibrotic disorders silicosis and asbestosis, respectively. Although alveolar macrophages are believed to initiate these inflammatory responses, the...