Nicholas T Woods
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Explore the profile of Nicholas T Woods including associated specialties, affiliations and a list of published articles.
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41
Citations
556
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Recent Articles
1.
Lum M, Jonas K, Parmar S, Black A, OConnor C, Dobersch S, et al.
J Clin Invest
. 2025 Jan;
135(4).
PMID: 39869680
Dysregulated eIF4E-dependent translation is a central driver of tumorigenesis and therapy resistance. eIF4E-binding proteins (4E-BP1/2/3) are major negative regulators of eIF4E-dependent translation that are inactivated in tumors through inhibitory phosphorylation...
2.
Lodovichi S, Nepomuceno T, Woods N, Rix U, Koomen J, Pellicioli A, et al.
iScience
. 2024 Nov;
27(11):111252.
PMID: 39569366
PARP1 inhibitors (PARPis) are used for treatment of cancers with mutations in or that are deficient in homologous recombination. The identification of modulators of PARP1 activity is critical to understand...
3.
Dobish K, Wittorf K, Swenson S, Bean D, Gavile C, Woods N, et al.
Leukemia
. 2023 Sep;
37(11):2197-2208.
PMID: 37689825
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by clonal expansion of myeloid blasts in the bone marrow (BM). Despite advances in therapy, the prognosis for AML patients remains...
4.
Plewes M, Talbott H, Saviola A, Woods N, Schott M, Davis J
Endocrinology
. 2023 Aug;
164(9).
PMID: 37586092
Progesterone is an essential steroid hormone that is required to initiate and maintain pregnancy in mammals and serves as a metabolic intermediate in the synthesis of endogenously produced steroids, including...
5.
Law H, Noe D, Woods N
Methods Mol Biol
. 2023 Aug;
2701:185-197.
PMID: 37574483
Immunoprecipitation-mass spectrometry (IP-MS) is a versatile tool to probe for global protein-protein interactions (PPIs) in biological samples. Such interactions coordinate complex biological processes, such as the DNA damage response (DDR)....
6.
Mallard H, Wan S, Nidhi P, Hanscom-Trofy Y, Mohapatra B, Woods N, et al.
Mol Cancer Res
. 2023 Jul;
21(11):1186-1204.
PMID: 37478161
Implications: High USP1 and replication stress levels driven by EWS::FLI1 transcription factor in EWS are vulnerabilities that can be exploited to improve existing treatment avenues and overcome drug resistance.
7.
Bhatia R, Thompson C, Clement E, Ganguly K, Cox J, Rauth S, et al.
Gastroenterology
. 2022 Jul;
163(4):1064-1078.e10.
PMID: 35788346
Background & Aims: Epidemiological studies have established alcohol and smoking as independent risk factors for recurrent acute pancreatitis and chronic pancreatitis. However, the molecular players responsible for the progressive loss...
8.
Ray S, Chee L, Zhou Y, Schaefer M, Naldrett M, Alvarez S, et al.
Elife
. 2022 Jun;
11.
PMID: 35713400
Acute anemia induces rapid expansion of erythroid precursors and accelerated differentiation to replenish erythrocytes. Paracrine signals-involving cooperation between stem cell factor (SCF)/Kit signaling and other signaling inputs-are required for the...
9.
Clement E, Law H, Qiao F, Noe D, Trevino J, Woods N
Cancers (Basel)
. 2022 Apr;
14(8).
PMID: 35454872
Pancreatic Ductal adenocarcinoma (PDAC) is an aggressive cancer commonly exhibiting KRAS-activating mutations. Alcohol contributes to the risk of developing PDAC in humans, and murine models have shown alcohol consumption in...
10.
Kour S, Rana S, Kubica S, Kizhake S, Ahmad M, Munoz-Trujillo C, et al.
J Biol Chem
. 2022 Apr;
298(5):101890.
PMID: 35378132
The unfolded protein response (UPR) is an adaptation mechanism activated to resolve transient accumulation of unfolded/misfolded proteins in the endoplasmic reticulum. Failure to resolve the transient accumulation of such proteins...