Michael S Cosgrove
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Explore the profile of Michael S Cosgrove including associated specialties, affiliations and a list of published articles.
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47
Citations
1764
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Recent Articles
1.
Pacherille A, Viernes D, Pedicone C, Fernandes S, Dungan O, Dormann S, et al.
ChemMedChem
. 2025 Jan;
:e202400597.
PMID: 39843392
The SH2-containing inositol phosphatase (SHIP) has become an actively researched therapeutic target for a number of disorders, including Alzheimer's Disease, Graft-vs-Host disease, obesity and cancer. Analogs of the aminosteroid SHIP...
2.
Barnes C, Salom D, Namitz K, Smith W, Knutson B, Cosgrove M, et al.
J Biol Chem
. 2024 Nov;
300(12):107966.
PMID: 39510183
Visual arrestin 1 (Arr1) is an essential protein for termination of the light response in photoreceptors. While mammalian Arr1s form dimers and tetramers at physiological concentrations in vitro, oligomerization in...
3.
Kobrossy L, Xu W, Zhang C, Feng W, Turner C, Cosgrove M
J Biol Chem
. 2024 Sep;
300(11):107825.
PMID: 39342993
Our understanding of acute leukemia pathology is heavily dependent on 11q23 chromosomal translocations involving the mixed lineage leukemia-1 (MLL1) gene, a key player in histone H3 lysine 4 (H3K4) methylation....
4.
Namitz K, Showalter S, Cosgrove M
J Biol Chem
. 2023 Sep;
299(10):105204.
PMID: 37660926
Enzymes that regulate the degree of histone H3 lysine 4 (H3K4) methylation are crucial for proper cellular differentiation and are frequently mutated in cancer. The Mixed lineage leukemia (MLL) family...
5.
Jain K, Marunde M, Burg J, Gloor S, Joseph F, Poncha K, et al.
Elife
. 2023 May;
12.
PMID: 37204295
In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini availability to the epigenetic machinery. Notably, H3...
6.
Namitz K, Tan S, Cosgrove M
J Biol Chem
. 2023 Jan;
299(2):102874.
PMID: 36623730
Enzymes of the mixed lineage leukemia (MLL) family of histone H3 lysine 4 (H3K4) methyltransferases are critical for cellular differentiation and development and are regulated by interaction with a conserved...
7.
Parallel functional annotation of cancer-associated missense mutations in histone methyltransferases
Canning A, Viggiano S, Fernandez-Zapico M, Cosgrove M
Sci Rep
. 2022 Nov;
12(1):18487.
PMID: 36323913
Using exome sequencing for biomarker discovery and precision medicine requires connecting nucleotide-level variation with functional changes in encoded proteins. However, for functionally annotating the thousands of cancer-associated missense mutations, or...
8.
Rahman S, Hoffmann N, Worden E, Smith M, Namitz K, Knutson B, et al.
Proc Natl Acad Sci U S A
. 2022 Sep;
119(38):e2205691119.
PMID: 36095189
The human Mixed Lineage Leukemia-1 (MLL1) complex methylates histone H3K4 to promote transcription and is stimulated by monoubiquitination of histone H2B. Recent structures of the MLL1-WRAD core complex, which comprises...
9.
Dao T, Yang Y, Presti M, Cosgrove M, Hopkins J, Ma W, et al.
EMBO Rep
. 2022 Jun;
23(8):e55056.
PMID: 35762418
Ubiquitin-binding shuttle UBQLN2 mediates crosstalk between proteasomal degradation and autophagy, likely via interactions with K48- and K63-linked polyubiquitin chains, respectively. UBQLN2 comprises self-associating regions that drive its homotypic liquid-liquid phase...
10.
Imran A, Moyer B, Kalina D, Duncan T, Moody K, Wolfe A, et al.
ACS Chem Biol
. 2022 May;
17(6):1586-1597.
PMID: 35613319
Progress in tumor sequencing and cancer databases has created an enormous amount of information that scientists struggle to sift through. While several research groups have created computational methods to analyze...