Stephen A Shinsky
Overview
Explore the profile of Stephen A Shinsky including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
582
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0
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Recent Articles
1.
Herp D, Ridinger J, Robaa D, Shinsky S, Schmidtkunz K, Yesiloglu T, et al.
Chembiochem
. 2022 May;
23(14):e202200180.
PMID: 35608330
Histone deacetylases (HDACs) are important epigenetic regulators involved in many diseases, especially cancer. Five HDAC inhibitors have been approved for anticancer therapy and many are in clinical trials. Among the...
2.
He H, Bian G, Herbst-Gervasoni C, Mori T, Shinsky S, Hou A, et al.
Nat Commun
. 2020 Aug;
11(1):3958.
PMID: 32769971
Catalytic versatility is an inherent property of many enzymes. In nature, terpene cyclases comprise the foundation of molecular biodiversity as they generate diverse hydrocarbon scaffolds found in thousands of terpenoid...
3.
Gowans G, Bridgers J, Zhang J, Dronamraju R, Burnetti A, King D, et al.
Mol Cell
. 2019 Nov;
76(6):909-921.e3.
PMID: 31676231
Metabolic signaling to chromatin often underlies how adaptive transcriptional responses are controlled. While intermediary metabolites serve as co-factors for histone-modifying enzymes during metabolic flux, how these modifications contribute to transcriptional...
4.
Osko J, Roose B, Shinsky S, Christianson D
Biochemistry
. 2019 Aug;
58(36):3755-3766.
PMID: 31436969
Polyamines are small organic cations that are essential for cellular function in all kingdoms of life. Polyamine metabolism is regulated by enzyme-catalyzed acetylation-deacetylation cycles in a fashion similar to the...
5.
Blank P, Shinsky S, Christianson D
ACS Chem Biol
. 2019 Apr;
14(5):1011-1019.
PMID: 30977996
The natural product sesquisabinene is a key component of the fragrant essential oil of the sandalwood tree, currently valued at $5,000/L. Sesquisabinene contains a highly strained [3.1.0] bicyclic ring system...
6.
Shinsky S, Christianson D
Biochemistry
. 2018 Mar;
57(22):3105-3114.
PMID: 29533602
Polyamines such as putrescine, spermidine, and spermine are small aliphatic cations that serve myriad biological functions in all forms of life. While polyamine biosynthesis and cellular trafficking pathways are generally...
7.
Hai Y, Shinsky S, Porter N, Christianson D
Nat Commun
. 2017 May;
8:15368.
PMID: 28516954
Cationic polyamines such as spermidine and spermine are critical in all forms of life, as they regulate the function of biological macromolecules. Intracellular polyamine metabolism is regulated by reversible acetylation...
8.
Shanle E, Shinsky S, Bridgers J, Bae N, Sagum C, Krajewski K, et al.
Epigenetics Chromatin
. 2017 Mar;
10:12.
PMID: 28293301
Background: Histone posttranslational modifications (PTMs) function to regulate chromatin structure and function in part through the recruitment of effector proteins that harbor specialized "reader" domains. Despite efforts to elucidate reader...
9.
Alicea-Velazquez N, Shinsky S, Loh D, Lee J, Skalnik D, Cosgrove M
J Biol Chem
. 2016 Aug;
291(43):22357-22372.
PMID: 27563068
MLL1 belongs to the SET1 family of histone H3 lysine 4 (H3K4) methyltransferases, composed of MLL1-4 and SETd1A/B. MLL1 translocations are present in acute leukemias, and mutations in several family...
10.
Hacker K, Fahey C, Shinsky S, Chiang Y, DiFiore J, Jha D, et al.
J Biol Chem
. 2016 Aug;
291(40):21283-21295.
PMID: 27528607
The yeast Set2 histone methyltransferase is a critical enzyme that plays a number of key roles in gene transcription and DNA repair. Recently, the human homologue, SETD2, was found to...