Venkatasubramanian Dharmarajan
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Explore the profile of Venkatasubramanian Dharmarajan including associated specialties, affiliations and a list of published articles.
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30
Citations
1148
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Recent Articles
1.
Zheng J, Strutzenberg T, Reich A, Dharmarajan V, Pascal B, Crynen G, et al.
Anal Chem
. 2020 Jul;
92(16):11018-11028.
PMID: 32658454
Hydrogen/Deuterium Exchange (HDX) coupled with Mass Spectrometry (HDX-MS) is a sensitive and robust method to probe protein conformational changes and protein-ligand interactions. HDX-MS relies on successful proteolytic digestion of target...
2.
Khan A, Jagielnicki M, McIntire W, Purdy M, Dharmarajan V, Griffin P, et al.
Cell Rep
. 2020 Apr;
31(3):107482.
PMID: 32320665
Gap junction channels (GJCs) mediate intercellular communication and are gated by numerous conditions such as pH. The electron cryomicroscopy (cryo-EM) structure of Cx26 GJC at physiological pH recapitulates previous GJC...
3.
Longbotham J, Chio C, Dharmarajan V, Trnka M, Ortiz Torres I, Goswami D, et al.
Nat Commun
. 2019 Jan;
10(1):94.
PMID: 30626866
Histone demethylase KDM5A removes methyl marks from lysine 4 of histone H3 and is often overexpressed in cancer. The in vitro demethylase activity of KDM5A is allosterically enhanced by binding...
4.
Fanning S, Jeselsohn R, Dharmarajan V, Mayne C, Karimi M, Buchwalter G, et al.
Elife
. 2018 Nov;
7.
PMID: 30489256
Acquired resistance to endocrine therapy remains a significant clinical burden for breast cancer patients. Somatic mutations in the (estrogen receptor alpha (ERα)) gene ligand-binding domain (LBD) represent a recognized mechanism...
5.
de Vera I, Munoz-Tello P, Zheng J, Dharmarajan V, Marciano D, Matta-Camacho E, et al.
Structure
. 2018 Nov;
27(1):66-77.e5.
PMID: 30416039
Nuclear receptor-related 1 protein (Nurr1/NR4A2) is an orphan nuclear receptor (NR) that is considered to function without a canonical ligand-binding pocket (LBP). A crystal structure of the Nurr1 ligand-binding domain...
6.
Doebelin C, Patouret R, Garcia-Ordonez R, Chang M, Dharmarajan V, Novick S, et al.
Bioorg Med Chem Lett
. 2018 Aug;
28(19):3210-3215.
PMID: 30143422
We sought to develop RORβ-selective probe molecules in order to investigate the function of the receptor in vitro and in vivo and its role in the pathophysiology of disease. To...
7.
Lin H, Doebelin C, Patouret R, Garcia-Ordonez R, Chang M, Dharmarajan V, et al.
Bioorg Med Chem Lett
. 2018 Mar;
28(8):1313-1319.
PMID: 29548571
Herein we report the design and synthesis of a series of simple phenol amide ERRγ agonists based on a hydrazone lead molecule. Our structure activity relationship studies in this series...
8.
Kurumbail R, West G, Dharmarajan V, Borzilleri K, Withka J, Ward J, et al.
Methods Mol Biol
. 2018 Feb;
1732:29-55.
PMID: 29480467
Protein-ligand interactions can be evaluated by a number of different biophysical methods. Here we describe some of the experimental methods that we have used to generate AMPK protein reagents and...
9.
Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, et al.
Nature
. 2017 May;
546(7657):259-264.
PMID: 28514451
The human glucagon receptor, GCGR, belongs to the class B G-protein-coupled receptor family and plays a key role in glucose homeostasis and the pathophysiology of type 2 diabetes. Here we...
10.
Srinivasan S, Nwachukwu J, Bruno N, Dharmarajan V, Goswami D, Kastrati I, et al.
Nat Chem Biol
. 2017 May;
13(6):691.
PMID: 28514424
No abstract available.