Michael S Cosgrove
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Explore the profile of Michael S Cosgrove including associated specialties, affiliations and a list of published articles.
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47
Citations
1764
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Recent Articles
11.
Imran A, Moyer B, Wolfe A, Cosgrove M, Makarov D, Movileanu L
J Phys Chem Lett
. 2022 Apr;
13(18):4021-4028.
PMID: 35485934
Surface-tethered ligand-receptor complexes are key components in biological signaling and adhesion. They also find increasing utility in single-molecule assays and biotechnological applications. Here, we study the real-time binding kinetics between...
12.
Mayse L, Imran A, Larimi M, Cosgrove M, Wolfe A, Movileanu L
Nat Commun
. 2022 Feb;
13(1):978.
PMID: 35190547
WD40 repeat proteins are frequently involved in processing cell signaling and scaffolding large multi-subunit machineries. Despite their significance in physiological and disease-like conditions, their reversible interactions with other proteins remain...
13.
Usher E, Namitz K, Cosgrove M, Showalter S
Biophys J
. 2021 Sep;
120(21):4710-4721.
PMID: 34592262
Post-translational modification (PTM) of proteins is of critical importance to the regulation of many cellular processes in eukaryotic organisms. One of the most well-studied protein PTMs is methylation, wherein an...
14.
Imran A, Moyer B, Canning A, Kalina D, Duncan T, Moody K, et al.
Biochem J
. 2021 May;
478(11):2145-2161.
PMID: 34032265
Recent advances in quantitative proteomics show that WD40 proteins play a pivotal role in numerous cellular networks. Yet, they have been fairly unexplored and their physical associations with other proteins...
15.
Namitz K, Zheng T, Canning A, Alicea-Velazquez N, Castaneda C, Cosgrove M, et al.
Commun Biol
. 2021 Mar;
4(1):398.
PMID: 33767358
Accurate gene transcription in eukaryotes depends on isomerization of serine-proline bonds within the carboxy-terminal domain (CTD) of RNA polymerase II. Isomerization is part of the "CTD code" that regulates recruitment...
16.
Zhao J, Blayney A, Liu X, Gandy L, Jin W, Yan L, et al.
Nat Commun
. 2021 Feb;
12(1):986.
PMID: 33579943
Epigallocatechin gallate (EGCG) from green tea can induce apoptosis in cancerous cells, but the underlying molecular mechanisms remain poorly understood. Using SPR and NMR, here we report a direct, μM...
17.
Dao T, Martyniak B, Canning A, Lei Y, Colicino E, Cosgrove M, et al.
Structure
. 2019 Apr;
27(6):937-951.e5.
PMID: 30982635
Proteasomal shuttle factor UBQLN2 is recruited to stress granules and undergoes liquid-liquid phase separation (LLPS) into protein-containing droplets. Mutations to UBQLN2 have recently been shown to cause dominant X-linked inheritance...
18.
Liao L, Alicea-Velazquez N, Langbein L, Niu X, Cai W, Cho E, et al.
Mol Oncol
. 2018 Dec;
13(4):811-828.
PMID: 30585695
Polybromo-1 (PBRM1) is an important tumor suppressor in kidney cancer. It contains six tandem bromodomains (BDs), which are specialized structures that recognize acetyl-lysine residues. While BD2 has been found to...
19.
Karchin J, Ha J, Namitz K, Cosgrove M, Loh S
Sci Rep
. 2017 Mar;
7:44388.
PMID: 28287617
Domain swapping is the process by which identical proteins exchange reciprocal segments to generate dimers. Here we introduce induced domain swapping (INDOS) as a mechanism for regulating protein function. INDOS...
20.
Alicea-Velazquez N, Shinsky S, Loh D, Lee J, Skalnik D, Cosgrove M
J Biol Chem
. 2016 Aug;
291(43):22357-22372.
PMID: 27563068
MLL1 belongs to the SET1 family of histone H3 lysine 4 (H3K4) methyltransferases, composed of MLL1-4 and SETd1A/B. MLL1 translocations are present in acute leukemias, and mutations in several family...