Valarie E Vought
Overview
Explore the profile of Valarie E Vought including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
599
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Recent Articles
1.
He Y, Jackman N, Thorn T, Vought V, Hewett S
Glia
. 2015 Apr;
63(9):1568-80.
PMID: 25880604
Astrocytes produce and export the antioxidant glutathione (GSH). Previously, we found that interleukin-1β (IL-1β) enhanced the expression of astrocyte system xc (-) , the transporter that delivers the rate-limiting substrate...
2.
Shinsky S, Hu M, Vought V, Ng S, Bamshad M, Shendure J, et al.
J Mol Biol
. 2014 Apr;
426(12):2283-99.
PMID: 24680668
The mixed lineage leukemia-1 (MLL1) enzyme is a histone H3 lysine 4 (H3K4) monomethyltransferase and has served as a paradigm for understanding the mechanism of action of the human SET1...
3.
Patel A, Vought V, Swatkoski S, Viggiano S, Howard B, Dharmarajan V, et al.
J Biol Chem
. 2013 Nov;
289(2):868-84.
PMID: 24235145
The mixed lineage leukemia-1 (MLL1) core complex predominantly catalyzes mono- and dimethylation of histone H3 at lysine 4 (H3K4) and is frequently altered in aggressive acute leukemias. The molecular mechanisms...
4.
Fox P, Vought V, Hanazawa M, Lee M, Maine E, Schedl T
Development
. 2011 May;
138(11):2223-34.
PMID: 21558371
The C. elegans germline provides an excellent model for analyzing the regulation of stem cell activity and the decision to differentiate and undergo meiotic development. The distal end of the...
5.
Wollert T, Patel A, Lee Y, Provance Jr D, Vought V, Cosgrove M, et al.
J Biol Chem
. 2011 Feb;
286(16):14352-61.
PMID: 21349835
Myosin-Va (Myo5a) is a motor protein associated with synaptic vesicles (SVs) but the mechanism by which it interacts has not yet been identified. A potential class of binding partners are...
6.
Patel A, Vought V, Dharmarajan V, Cosgrove M
J Biol Chem
. 2010 Nov;
286(5):3359-69.
PMID: 21106533
Gene expression within the context of eukaryotic chromatin is regulated by enzymes that catalyze histone lysine methylation. Histone lysine methyltransferases that have been identified to date possess the evolutionarily conserved...
7.
Patel A, Dharmarajan V, Vought V, Cosgrove M
J Biol Chem
. 2009 Jun;
284(36):24242-56.
PMID: 19556245
Transcription in eukaryotic genomes depends on enzymes that regulate the degree of histone H3 lysine 4 (H3K4) methylation. The mixed lineage leukemia protein-1 (MLL1) is a member of the SET1...
8.
Patel A, Vought V, Dharmarajan V, Cosgrove M
J Biol Chem
. 2008 Oct;
283(47):32162-75.
PMID: 18829457
The mixed lineage leukemia protein-1 (MLL1) belongs to the SET1 family of histone H3 lysine 4 methyltransferases. Recent studies indicate that the catalytic subunits of SET1 family members are regulated...
9.
Yu X, Vought V, Conradt B, Maine E
Genesis
. 2006 Aug;
44(9):412-8.
PMID: 16937415
In C. elegans, a population of proliferating germ cells is maintained via GLP-1/Notch signaling; in the absence of GLP-1 signaling, germ cells prematurely enter meiosis and differentiate. We previously identified...
10.
Maine E, Hauth J, Ratliff T, Vought V, She X, Kelly W
Curr Biol
. 2005 Nov;
15(21):1972-8.
PMID: 16271877
During meiosis in C. elegans, unpaired chromosomes and chromosomal regions accumulate high levels of histone H3 lysine 9 dimethylation (H3K9me2), a modification associated with facultative heterochromatin assembly and the resulting...