Kevin E W Namitz
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Explore the profile of Kevin E W Namitz including associated specialties, affiliations and a list of published articles.
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11
Citations
53
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Recent Articles
1.
Barnes C, Salom D, Namitz K, Smith W, Knutson B, Cosgrove M, et al.
J Biol Chem
. 2024 Nov;
300(12):107966.
PMID: 39510183
Visual arrestin 1 (Arr1) is an essential protein for termination of the light response in photoreceptors. While mammalian Arr1s form dimers and tetramers at physiological concentrations in vitro, oligomerization in...
2.
Lu X, Cummings C, Osuala U, Yennawar N, Namitz K, Hellner B, et al.
Analyst
. 2024 May;
149(13):3636-3650.
PMID: 38814097
This work presents a thorough characterization of Helaina recombinant human lactoferrin (rhLF, Effera™) expressed in a yeast system at an industrial scale for the first time. Proteomic analysis confirmed that...
3.
Namitz K, Showalter S, Cosgrove M
J Biol Chem
. 2023 Sep;
299(10):105204.
PMID: 37660926
Enzymes that regulate the degree of histone H3 lysine 4 (H3K4) methylation are crucial for proper cellular differentiation and are frequently mutated in cancer. The Mixed lineage leukemia (MLL) family...
4.
Fraser O, Namitz K, Showalter S
Methods
. 2023 Jul;
218:72-83.
PMID: 37524235
Post-translational modifications (PTMs) are reversible chemical modifications that can modulate protein structure and function. Methylation and acetylation are two such PTMs with integral and well-characterized biological roles, including modulation of...
5.
Jain K, Marunde M, Burg J, Gloor S, Joseph F, Poncha K, et al.
Elife
. 2023 May;
12.
PMID: 37204295
In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini availability to the epigenetic machinery. Notably, H3...
6.
Namitz K, Tan S, Cosgrove M
J Biol Chem
. 2023 Jan;
299(2):102874.
PMID: 36623730
Enzymes of the mixed lineage leukemia (MLL) family of histone H3 lysine 4 (H3K4) methyltransferases are critical for cellular differentiation and development and are regulated by interaction with a conserved...
7.
Rahman S, Hoffmann N, Worden E, Smith M, Namitz K, Knutson B, et al.
Proc Natl Acad Sci U S A
. 2022 Sep;
119(38):e2205691119.
PMID: 36095189
The human Mixed Lineage Leukemia-1 (MLL1) complex methylates histone H3K4 to promote transcription and is stimulated by monoubiquitination of histone H2B. Recent structures of the MLL1-WRAD core complex, which comprises...
8.
Palumbo R, McKean N, Leatherman E, Namitz K, Connell L, Wolfe A, et al.
Sci Adv
. 2022 Sep;
8(36):eabq3235.
PMID: 36070379
Most of the world's biodiversity lives in cold (-2° to 4°C) and hypersaline environments. To understand how cells adapt to such conditions, we isolated two key components of the transcription...
9.
Usher E, Namitz K, Cosgrove M, Showalter S
Biophys J
. 2021 Sep;
120(21):4710-4721.
PMID: 34592262
Post-translational modification (PTM) of proteins is of critical importance to the regulation of many cellular processes in eukaryotic organisms. One of the most well-studied protein PTMs is methylation, wherein an...
10.
Prieto V, Namitz K, Showalter S
J Phys Chem B
. 2021 Sep;
125(39):10917-10927.
PMID: 34550709
Intrinsically disordered protein (IDP) sequences often contain a high proportion of charged residues in conjunction with their high degree of hydrophilicity and solvation. For high net charge IDPs, long-range electrostatic...