Michael C Ostrowski
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Explore the profile of Michael C Ostrowski including associated specialties, affiliations and a list of published articles.
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115
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5422
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Recent Articles
31.
Pitarresi J, Liu X, Avendano A, Thies K, Sizemore G, Hammer A, et al.
Life Sci Alliance
. 2018 Nov;
1(5):e201800190.
PMID: 30456390
The contribution of the tumor microenvironment to pancreatic ductal adenocarcinoma (PDAC) development is currently unclear. We therefore examined the consequences of disrupting paracrine Hedgehog (HH) signaling in PDAC stroma. Herein,...
32.
Sizemore S, Zhang M, Cho J, Sizemore G, Hurwitz B, Kaur B, et al.
Cell Res
. 2018 Oct;
28(11):1090-1102.
PMID: 30297868
Resistance to genotoxic therapies is a primary cause of treatment failure and tumor recurrence. The underlying mechanisms that activate the DNA damage response (DDR) and allow cancer cells to escape...
33.
Sizemore G, Balakrishnan S, Thies K, Hammer A, Sizemore S, Trimboli A, et al.
Nat Commun
. 2018 Jul;
9(1):2783.
PMID: 30018330
The importance of the tumor-associated stroma in cancer progression is clear. However, it remains uncertain whether early events in the stroma are capable of initiating breast tumorigenesis. Here, we show...
34.
Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation
Ahirwar D, Nasser M, Ouseph M, Elbaz M, Cuitino M, Kladney R, et al.
Oncogene
. 2018 May;
37(32):4428-4442.
PMID: 29720724
The chemokine CXCL12 has been shown to regulate breast tumor growth, however, its mechanism in initiating distant metastasis is not well understood. Here, we generated a novel conditional allele of...
35.
Carey H, Hildreth 3rd B, Geisler J, Nickel M, Cabrera J, Ghosh S, et al.
Bone Res
. 2018 Apr;
6:8.
PMID: 29619268
Genome-wide association studies (GWASs) have been instrumental in understanding complex phenotypic traits. However, they have rarely been used to understand lineage-specific pathways and functions that contribute to the trait. In...
36.
Sizemore S, Mohammad R, Sizemore G, Nowsheen S, Yu H, Ostrowski M, et al.
Mol Cancer Res
. 2018 Mar;
16(7):1092-1102.
PMID: 29592899
PARP inhibitors (PARPi) are potentially effective therapeutic agents capable of inducing synthetic lethality in tumors with deficiencies in homologous recombination (HR)-mediated DNA repair such as those carrying BRCA1 mutations. However,...
37.
Hawley C, Rojo R, Raper A, Sauter K, Lisowski Z, Grabert K, et al.
J Immunol
. 2018 Feb;
200(6):2209-2223.
PMID: 29440354
CSF1 is the primary growth factor controlling macrophage numbers, but whether expression of the CSF1 receptor differs between discrete populations of mononuclear phagocytes remains unclear. We have generated a -mApple...
38.
Pourebrahim R, Zhang Y, Liu B, Gao R, Xiong S, Lin P, et al.
Genes Dev
. 2017 Oct;
31(18):1847-1857.
PMID: 29021240
is the most frequently mutated gene in human cancer. Many mutant p53 proteins exert oncogenic gain-of-function (GOF) properties that contribute to metastasis, but the mechanisms mediating these functions remain poorly...
39.
Wu J, Liu X, Nayak S, Pitarresi J, Cuitino M, Yu L, et al.
PLoS One
. 2017 Sep;
12(9):e0184984.
PMID: 28934293
The contribution of the tumor microenvironment to the development of pancreatic adenocarcinoma (PDAC) is unclear. The LSL-KrasG12D/+;LSL-p53R172H/+;Pdx-1-Cre (KPC) tumor model, which is widely utilized to faithfully recapitulate human pancreatic cancer,...
40.
Victor A, Nalin A, Dong W, McClory S, Wei M, Mao C, et al.
J Immunol
. 2017 Aug;
199(7):2333-2342.
PMID: 28842466
Group 3 innate lymphoid cells (ILC3s) are important regulators of the immune system, maintaining homeostasis in the presence of commensal bacteria, but activating immune defenses in response to microbial pathogens....