Raleigh D Kladney
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Explore the profile of Raleigh D Kladney including associated specialties, affiliations and a list of published articles.
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28
Citations
996
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Recent Articles
1.
Kung C, Terzich N, Ilagen M, Prinsen M, Kaushal M, Kladney R, et al.
bioRxiv
. 2025 Feb;
PMID: 39896528
Triple-negative breast cancer (TNBC), lacking expression of estrogen, progesterone, and HER2 receptors, is aggressive and lacks targeted treatment options. An RNA editing enzyme, adenosine deaminase acting on RNA 1 (ADAR1),...
2.
Kung C, Cottrell K, Ryu S, Bramel E, Kladney R, Bao E, et al.
Oncogene
. 2021 Feb;
40(11):2147.
PMID: 33564075
No abstract available.
3.
Kung C, Cottrell K, Ryu S, Bramel E, Kladney R, Bao E, et al.
Oncogene
. 2020 Oct;
40(1):189-202.
PMID: 33110236
Triple-negative breast cancer (TNBC) is the deadliest form of breast cancer. Unlike other types of breast cancer that can be effectively treated by targeted therapies, no such targeted therapy exists...
4.
Park D, Bergin S, Jones D, Ru P, Koivisto C, Jeon Y, et al.
Cancer Res
. 2020 Aug;
80(19):4172-4184.
PMID: 32732220
Heterozygous mutations in the gene predispose women to breast and ovarian cancer, while biallelic BRCA1 mutations are a cause of Fanconi anemia (FA), a rare genetic disorder characterized by developmental...
5.
Thies K, Hammer A, Hildreth 3rd B, Steck S, Spehar J, Kladney R, et al.
Cancer Res
. 2020 Apr;
81(3):606-618.
PMID: 32327406
Platelet-derived growth factor receptor-beta (PDGFRβ) is a receptor tyrosine kinase found in cells of mesenchymal origin such as fibroblasts and pericytes. Activation of this receptor is dependent on paracrine ligand...
6.
Pitarresi J, Liu X, Avendano A, Thies K, Sizemore G, Hammer A, et al.
Life Sci Alliance
. 2018 Nov;
1(5):e201800190.
PMID: 30456390
The contribution of the tumor microenvironment to pancreatic ductal adenocarcinoma (PDAC) development is currently unclear. We therefore examined the consequences of disrupting paracrine Hedgehog (HH) signaling in PDAC stroma. Herein,...
7.
Sizemore G, Balakrishnan S, Thies K, Hammer A, Sizemore S, Trimboli A, et al.
Nat Commun
. 2018 Jul;
9(1):2783.
PMID: 30018330
The importance of the tumor-associated stroma in cancer progression is clear. However, it remains uncertain whether early events in the stroma are capable of initiating breast tumorigenesis. Here, we show...
8.
Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation
Ahirwar D, Nasser M, Ouseph M, Elbaz M, Cuitino M, Kladney R, et al.
Oncogene
. 2018 May;
37(32):4428-4442.
PMID: 29720724
The chemokine CXCL12 has been shown to regulate breast tumor growth, however, its mechanism in initiating distant metastasis is not well understood. Here, we generated a novel conditional allele of...
9.
Saini U, Suarez A, Naidu S, Wallbillich J, Bixel K, Wanner R, et al.
Cancer Res
. 2018 Jan;
78(7):1739-1750.
PMID: 29339537
The initial molecular events that lead to malignant transformation of the fimbria of the fallopian tube (FT) through high-grade serous ovarian carcinoma (HGSC) remain poorly understood. In this study, we...
10.
Ratnam N, Peterson J, Talbert E, Ladner K, Rajasekera P, Schmidt C, et al.
J Clin Invest
. 2017 Sep;
127(10):3796-3809.
PMID: 28891811
Macrophages are attracted to developing tumors and can participate in immune surveillance to eliminate neoplastic cells. In response, neoplastic cells utilize NF-κB to suppress this killing activity, but the mechanisms...