Michael C Ostrowski
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Explore the profile of Michael C Ostrowski including associated specialties, affiliations and a list of published articles.
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115
Citations
5422
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Recent Articles
41.
Liu H, Dowdle J, Khurshid S, Sullivan N, Bertos N, Rambani K, et al.
Dev Cell
. 2017 May;
41(4):392-407.e6.
PMID: 28535374
Mesodermal cells signal to neighboring epithelial cells to modulate their proliferation in both normal and disease states. We adapted a Caenorhabditis elegans organogenesis model to enable a genome-wide mesodermal-specific RNAi...
42.
Hammer A, Sizemore G, Shukla V, Avendano A, Sizemore S, Chang J, et al.
Neoplasia
. 2017 May;
19(6):496-508.
PMID: 28501760
The extracellular matrix (ECM) is critical for mammary ductal development and differentiation, but how mammary fibroblasts regulate ECM remodeling remains to be elucidated. Herein, we used a mouse genetic model...
43.
Komar H, Serpa G, Kerscher C, Schwoegl E, Mace T, Jin M, et al.
Sci Rep
. 2017 May;
7(1):1787.
PMID: 28496202
Chronic pancreatitis (CP) is a fibro-inflammatory disease leading to pain, maldigestion, and pancreatic insufficiency. No therapeutic options exist due to a limited understanding of the biology of CP pathology. Recent...
44.
Sizemore G, Pitarresi J, Balakrishnan S, Ostrowski M
Nat Rev Cancer
. 2017 Apr;
17(6):337-351.
PMID: 28450705
Findings over the past decade have identified aberrant activation of the ETS transcription factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene rearrangement and amplification, feed-forward growth...
45.
Mace T, Shakya R, Pitarresi J, Swanson B, McQuinn C, Loftus S, et al.
Gut
. 2016 Nov;
67(2):320-332.
PMID: 27797936
Objective: Limited efficacy of immune checkpoint inhibitors in pancreatic ductal adenocarcinoma (PDAC) has prompted investigation into combination therapy. We hypothesised that interleukin 6 (IL-6) blockade would modulate immunological features of...
46.
Pitarresi J, Liu X, Sharma S, Cuitino M, Kladney R, Mace T, et al.
Neoplasia
. 2016 Sep;
18(9):541-52.
PMID: 27659014
Preclinical studies have suggested that the pancreatic tumor microenvironment both inhibits and promotes tumor development and growth. Here we establish the role of stromal fibroblasts during acinar-to-ductal metaplasia (ADM), an...
47.
Liu X, Pitarresi J, Cuitino M, Kladney R, Woelke S, Sizemore G, et al.
Genes Dev
. 2016 Sep;
30(17):1943-55.
PMID: 27633013
The contribution of the microenvironment to pancreatic acinar-to-ductal metaplasia (ADM), a preneoplastic transition in oncogenic Kras-driven pancreatic cancer progression, is currently unclear. Here we show that disruption of paracrine Hedgehog...
48.
Chaffee B, Hoang T, Leonard M, Bruney D, Wagner B, Dowd J, et al.
Dev Biol
. 2016 Jan;
410(2):150-163.
PMID: 26764128
Lens epithelial cells express many receptor tyrosine kinases (RTKs) that stimulate PI3K-AKT and RAS-RAF-MEK-ERK intracellular signaling pathways. These pathways ultimately activate the phosphorylation of key cellular transcription factors and other...
49.
Mace T, Shakya R, Elnaggar O, Wilson K, Komar H, Yang J, et al.
Oncotarget
. 2015 Nov;
6(42):44509-22.
PMID: 26575024
The Jak/STAT pathway is activated in human pancreatic ductal adenocarcinoma (PDAC) and cooperates with mutant Kras to drive initiation and progression of PDAC in murine models. We hypothesized that the...
50.
Caserta E, Egriboz O, Wang H, Martin C, Koivisto C, Pecot T, et al.
Genes Dev
. 2015 Aug;
29(16):1707-20.
PMID: 26302789
Inactivation of phosphatase and tensin homology deleted on chromosome 10 (PTEN) is linked to increased PI3K-AKT signaling, enhanced organismal growth, and cancer development. Here we generated and analyzed Pten knock-in...