Michael C Ostrowski
Overview
Explore the profile of Michael C Ostrowski including associated specialties, affiliations and a list of published articles.
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Articles
115
Citations
5422
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Recent Articles
21.
McCarter A, Della Gatta G, Melnick A, Kim E, Sha C, Wang Q, et al.
Blood Cancer Discov
. 2020 Sep;
1(2):178-197.
PMID: 32924017
Notch activation is highly prevalent among cancers, in particular T-cell acute lymphoblastic leukemia (T-ALL). However, the use of pan-Notch inhibitors to treat cancers has been hampered by adverse effects, particularly...
22.
Thies K, Hammer A, Hildreth 3rd B, Steck S, Spehar J, Kladney R, et al.
Cancer Res
. 2020 Apr;
81(3):606-618.
PMID: 32327406
Platelet-derived growth factor receptor-beta (PDGFRβ) is a receptor tyrosine kinase found in cells of mesenchymal origin such as fibroblasts and pericytes. Activation of this receptor is dependent on paracrine ligand...
23.
Thies K, Lefler J, Leone G, Ostrowski M
Cold Spring Harb Perspect Med
. 2019 Aug;
9(10).
PMID: 31427286
Although tremendous progress has been made in understanding the functions of (PTEN) in tumor cells, only recently have tumor cell-non-autonomous actions within the tumor microenvironment (TME) been appreciated. While it...
24.
Talbert E, Cuitino M, Ladner K, Rajasekerea P, Siebert M, Shakya R, et al.
Cell Rep
. 2019 Aug;
28(6):1612-1622.e4.
PMID: 31390573
Cachexia is a wasting syndrome characterized by pronounced skeletal muscle loss. In cancer, cachexia is associated with increased morbidity and mortality and decreased treatment tolerance. Although advances have been made...
25.
Bowen C, Ostrowski M, Leone G, Gelmann E
Cancer Res
. 2019 Jun;
79(16):4124-4134.
PMID: 31213464
is the most commonly deleted gene in prostate cancer and a gatekeeper suppressor. NKX3.1 is a growth suppressor, mediator of apoptosis, inducer of antioxidants, and enhancer of DNA repair. PTEN...
26.
Cuitino M, Pecot T, Sun D, Kladney R, Okano-Uchida T, Shinde N, et al.
Cell Rep
. 2019 May;
27(12):3547-3560.e5.
PMID: 31130414
Orchestrating cell-cycle-dependent mRNA oscillations is critical to cell proliferation in multicellular organisms. Even though our understanding of cell-cycle-regulated transcription has improved significantly over the last three decades, the mechanisms remain...
27.
Xu L, Fu M, Chen D, Han W, Ostrowski M, Grossfeld P, et al.
BMB Rep
. 2019 Jan;
52(10):595-600.
PMID: 30670148
Cardiac fibrosis is a common feature in chronic hypertension patients with advanced heart failure, and endothelial-tomesenchymal transition (EndMT) is known to promote Angiotensin II (Ang II)-mediated cardiac fibrosis. Previous studies...
28.
Carey H, Hildreth 3rd B, Samuvel D, Thies K, Rosol T, Toribio R, et al.
iScience
. 2019 Jan;
11:238-245.
PMID: 30634169
Bone-resorbing osteoclasts (OCs) are derived from myeloid precursors (MPs). Several transcription factors are implicated in OC differentiation and function; however, their hierarchical architecture and interplay are not well known. Analysis...
29.
Jones C, Hammer A, Cho Y, Sizemore G, Cukierman E, Yee L, et al.
Neoplasia
. 2018 Dec;
21(1):132-145.
PMID: 30550871
The organization of the extracellular matrix has a profound impact on cancer development and progression. The matrix becomes aligned throughout tumor progression, providing "highways" for tumor cell invasion. Aligned matrix...
30.
Russell L, Swanner J, Jaime-Ramirez A, Wang Y, Sprague A, Banasavadi-Siddegowda Y, et al.
Nat Commun
. 2018 Nov;
9(1):5006.
PMID: 30479334
Engineered oncolytic viruses are used clinically to destroy cancer cells and have the ability to boost anticancer immunity. Phosphatase and tensin homolog deleted on chromosome 10 loss is common across...