Nicholas C Poulton
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Explore the profile of Nicholas C Poulton including associated specialties, affiliations and a list of published articles.
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9
Citations
237
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0
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Recent Articles
1.
Eckartt K, Delbeau M, Munsamy-Govender V, DeJesus M, Azadian Z, Reddy A, et al.
Nature
. 2024 Mar;
628(8006):186-194.
PMID: 38509362
Drug-resistant bacteria are emerging as a global threat, despite frequently being less fit than their drug-susceptible ancestors. Here we sought to define the mechanisms that drive or buffer the fitness...
2.
Poulton N, DeJesus M, Munsamy-Govender V, Kanai M, Roberts C, Azadian Z, et al.
Cell Chem Biol
. 2024 Jan;
31(4):669-682.e7.
PMID: 38266648
Pathogenic mycobacteria are a significant cause of morbidity and mortality worldwide. The conserved whiB7 stress response reduces the effectiveness of antibiotic therapy by activating several intrinsic antibiotic resistance mechanisms. Despite...
3.
Poulton N, DeJesus M, Munsamy-Govender V, Roberts C, Azadian Z, Bosch B, et al.
bioRxiv
. 2023 Jun;
PMID: 37333137
Pathogenic mycobacteria are a significant cause of morbidity and mortality worldwide. These bacteria are highly intrinsically drug resistant, making infections challenging to treat. The conserved stress response is a key...
4.
Wong A, Beites T, Planck K, Fieweger R, Eckartt K, Li S, et al.
Elife
. 2023 Feb;
12.
PMID: 36810158
Cyclic AMP (cAMP) is a ubiquitous second messenger that transduces signals from cellular receptors to downstream effectors. (Mtb), the etiological agent of tuberculosis, devotes a considerable amount of coding capacity...
5.
Poulton N, Rock J
Front Cell Infect Microbiol
. 2022 Nov;
12:997283.
PMID: 36325467
Tuberculosis (TB) is among the most difficult infections to treat, requiring several months of multidrug therapy to produce a durable cure. The reasons necessitating long treatment times are complex and...
6.
Poulton N, Azadian Z, DeJesus M, Rock J
Antimicrob Agents Chemother
. 2022 Aug;
66(9):e0090422.
PMID: 35920665
Tuberculosis (TB) is the leading cause of death from any bacterial infection, causing 1.5 million deaths worldwide each year. Due to the emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb)...
7.
Li S, Poulton N, Chang J, Azadian Z, DeJesus M, Ruecker N, et al.
Nat Microbiol
. 2022 May;
7(6):766-779.
PMID: 35637331
Mycobacterium tuberculosis (Mtb) infection is notoriously difficult to treat. Treatment efficacy is limited by Mtb's intrinsic drug resistance, as well as its ability to evolve acquired resistance to all antituberculars...
8.
dAndrea F, Poulton N, Froom R, Tam K, Campbell E, Rock J
Sci Adv
. 2022 May;
8(18):eabn7943.
PMID: 35507665
The Clp protease system is a promising, noncanonical drug target against (Mtb). Unlike in , the Mtb Clp protease consists of two distinct proteolytic subunits, ClpP1 and ClpP2, which hydrolyze...
9.
Bosch B, DeJesus M, Poulton N, Zhang W, Engelhart C, Zaveri A, et al.
Cell
. 2021 Jul;
184(17):4579-4592.e24.
PMID: 34297925
Antibacterial agents target the products of essential genes but rarely achieve complete target inhibition. Thus, the all-or-none definition of essentiality afforded by traditional genetic approaches fails to discern the most...