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Marjolein Soethoudt

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Articles 17
Citations 588
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Recent Articles
1.
Bus-Jacobs L, Lau R, Soethoudt M, Gebbia L, Janssens E, Hermans T
Emerg Infect Dis . 2024 Mar; 30(4):757-760. PMID: 38526137
Analyzing vaccine stability under different storage and transportation conditions is critical to ensure that effectiveness and safety are not affected by distribution. In a simulation of the last mile in...
2.
Bouma J, Soethoudt M, van Gils N, Xia L, van der Stelt M, Heitman L
Methods Mol Biol . 2022 Sep; 2576:189-199. PMID: 36152187
Cannabinoid receptor 1 (CBR) and cannabinoid receptor 2 (CBR) are G protein-coupled receptors (GPCRs) that activate a variety of pathways upon activation by (partial) agonists including the G protein pathway...
3.
Mock E, Mustafa M, Gunduz-Cinar O, Cinar R, Petrie G, Kantae V, et al.
Nat Chem Biol . 2020 May; 16(6):667-675. PMID: 32393901
N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper...
4.
Yang X, Michiels T, de Jong C, Soethoudt M, Dekker N, Gordon E, et al.
J Med Chem . 2018 Aug; 61(17):7892-7901. PMID: 30080404
Using activity-based protein profiling (ABPP), functional proteins can be interrogated in their native environment. Despite their pharmaceutical relevance, G protein-coupled receptors (GPCRs) have been difficult to address through ABPP. In...
5.
Soethoudt M, Alachouzos G, van Rooden E, Moya-Garzon M, van den Berg R, Heitman L, et al.
Cannabis Cannabinoid Res . 2018 Jul; 3(1):136-151. PMID: 29992186
Δ-Tetrahydrocannabinol (THC), the principle psychoactive ingredient in , is widely used for its therapeutic effects in a large variety of diseases, but it also has numerous neurological side effects. The...
6.
Soethoudt M, Hoorens M, Doelman W, Martella A, van der Stelt M, Heitman L
Biochem Pharmacol . 2018 Mar; 152:129-142. PMID: 29574067
A decade ago, the drug-target residence time model has been (re-)introduced, which describes the importance of binding kinetics of ligands on their protein targets. Since then, it has been applied...
7.
Soethoudt M, Stolze S, Westphal M, van Stralen L, Martella A, van Rooden E, et al.
J Am Chem Soc . 2018 Feb; 140(19):6067-6075. PMID: 29420021
Chemical tools and methods that report on G protein-coupled receptor (GPCR) expression levels and receptor occupancy by small molecules are highly desirable. We report the development of LEI121 as a...
8.
van Esbroeck A, Janssen A, Cognetta 3rd A, Ogasawara D, Shpak G, van der Kroeg M, et al.
Science . 2017 Jun; 356(6342):1084-1087. PMID: 28596366
A recent phase 1 trial of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474 led to the death of one volunteer and produced mild-to-severe neurological symptoms in four others....
9.
Soethoudt M, Grether U, Fingerle J, Grim T, Fezza F, De Petrocellis L, et al.
Nat Commun . 2017 Jan; 8:13958. PMID: 28045021
The cannabinoid CB receptor (CBR) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target...
10.
Soethoudt M, van Gils N, van der Stelt M, Heitman L
Methods Mol Biol . 2016 Jun; 1412:103-11. PMID: 27245896
Cannabinoid CB1 and CB2 receptors are G-protein-coupled receptors (GPCRs) that recruit β-arrestins upon activation by (partial) agonists. β-Arrestin recruitment is induced by phosphorylation of their C-terminal tails, and is associated...