Laura H Heitman
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Explore the profile of Laura H Heitman including associated specialties, affiliations and a list of published articles.
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147
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2367
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Recent Articles
1.
Straub V, Barti B, Tandar S, Stevens A, van Egmond N, van der Wel T, et al.
Proc Natl Acad Sci U S A
. 2025 Feb;
122(8):e2421717122.
PMID: 39977325
While it is known that endocannabinoids (eCB) modulate multiple neuronal functions, the molecular mechanism governing their release and transport remains elusive. Here, we propose an "" model, wherein the formation...
2.
Beerkens B, IJzerman A, Heitman L, van der Es D
RSC Chem Biol
. 2025 Feb;
PMID: 39957994
Roughly one-third of all marketed drugs act by binding to one or more of the >800 human GPCRs, primarily through activation or inhibition the orthosteric binding site. In addition, novel...
3.
van Oostveen W, Hoekstra E, Levarht E, Kotliar I, Sakmar T, Toes R, et al.
Arthritis Rheumatol
. 2024 Dec;
PMID: 39721751
Objective: Systemic sclerosis (SSc) is a rare but severe autoimmune disease characterized by immune dysregulation, fibrosis, and vasculopathy. Although previous studies have highlighted the presence of functional autoantibodies targeting the...
4.
Feng C, Liu R, Brooks R, Wang X, Jespers W, Gorostiola Gonzalez M, et al.
Eur J Pharmacol
. 2024 Oct;
985:177081.
PMID: 39481631
The serotonin 5-HT receptor is a G protein-coupled receptor (GPCR) mainly expressed in the central nervous system. Besides regulating mood, appetite, and reproductive behavior, it has been identified as a...
5.
Stereochemical optimization of ,2-substituted cycloalkylamines as norepinephrine reuptake inhibitors
Dilweg M, Mocking T, Maragkoudakis P, van Westen G, Heitman L, IJzerman A, et al.
RSC Med Chem
. 2024 Sep;
PMID: 39345718
The norepinephrine transporter (NET), encoded by the SLC6A2 gene, is one of three key monoamine neurotransmitter transporters. Inhibition of NET-mediated reuptake of norepinephrine by monoamine reuptake inhibitors has been the...
6.
Aebi J, Atz K, Ametamey S, Benz J, Blaising J, Butini S, et al.
Chimia (Aarau)
. 2024 Sep;
78(7-8):499-512.
PMID: 39221845
The endocannabinoid system (ECS) is a critical regulatory network composed of endogenous cannabinoids (eCBs), their synthesizing and degrading enzymes, and associated receptors. It is integral to maintaining homeostasis and orchestrating...
7.
Ortiz Zacarias N, Roth S, Broekhuis J, van der Es D, Moreau K, Heitman L
Int J Mol Sci
. 2024 Aug;
25(16).
PMID: 39201670
CC chemokine receptor 2 (CCR2) has been linked to many inflammatory and immune diseases, making it a relevant drug target. Yet, all CCR2 antagonists developed so far have failed in...
8.
den Hollander L, Beerkens B, Dekkers S, Veldhoven J, Ortiz Zacarias N, van der Horst C, et al.
ACS Chem Biol
. 2024 Aug;
19(9):2070-2080.
PMID: 39186040
Interest in affinity-based probes (AfBPs) as novel tools to interrogate G protein-coupled receptors (GPCRs) has gained traction in recent years. AfBPs represent an interesting and more versatile alternative to antibodies....
9.
den Hollander L, Zweemer A, Bequignon O, Hammerl D, Bleijs B, Veenhuizen M, et al.
Biochem Pharmacol
. 2024 Aug;
229:116464.
PMID: 39111604
CC chemokine receptor 2 and CCL2 are highly involved in cancer growth and metastasis, and immune escape. Raised sodium ion concentrations in solid tumours have also been correlated to metastasis...
10.
Digles D, Ingles-Prieto A, Dvorak V, Mocking T, Goldmann U, Garofoli A, et al.
Front Pharmacol
. 2024 Jul;
15:1401599.
PMID: 39050757
With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human cells. SLCs are associated with...