Adriaan P IJzerman
Overview
Explore the profile of Adriaan P IJzerman including associated specialties, affiliations and a list of published articles.
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236
Citations
5561
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Recent Articles
1.
Beerkens B, IJzerman A, Heitman L, van der Es D
RSC Chem Biol
. 2025 Feb;
PMID: 39957994
Roughly one-third of all marketed drugs act by binding to one or more of the >800 human GPCRs, primarily through activation or inhibition the orthosteric binding site. In addition, novel...
2.
Stereochemical optimization of ,2-substituted cycloalkylamines as norepinephrine reuptake inhibitors
Dilweg M, Mocking T, Maragkoudakis P, van Westen G, Heitman L, IJzerman A, et al.
RSC Med Chem
. 2024 Sep;
PMID: 39345718
The norepinephrine transporter (NET), encoded by the SLC6A2 gene, is one of three key monoamine neurotransmitter transporters. Inhibition of NET-mediated reuptake of norepinephrine by monoamine reuptake inhibitors has been the...
3.
den Hollander L, Beerkens B, Dekkers S, Veldhoven J, Ortiz Zacarias N, van der Horst C, et al.
ACS Chem Biol
. 2024 Aug;
19(9):2070-2080.
PMID: 39186040
Interest in affinity-based probes (AfBPs) as novel tools to interrogate G protein-coupled receptors (GPCRs) has gained traction in recent years. AfBPs represent an interesting and more versatile alternative to antibodies....
4.
den Hollander L, Zweemer A, Bequignon O, Hammerl D, Bleijs B, Veenhuizen M, et al.
Biochem Pharmacol
. 2024 Aug;
229:116464.
PMID: 39111604
CC chemokine receptor 2 and CCL2 are highly involved in cancer growth and metastasis, and immune escape. Raised sodium ion concentrations in solid tumours have also been correlated to metastasis...
5.
Digles D, Ingles-Prieto A, Dvorak V, Mocking T, Goldmann U, Garofoli A, et al.
Front Pharmacol
. 2024 Jul;
15:1401599.
PMID: 39050757
With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human cells. SLCs are associated with...
6.
Beerkens B, Andrianopoulou V, Wang X, Liu R, van Westen G, Jespers W, et al.
ACS Chem Biol
. 2024 Jun;
19(7):1554-1562.
PMID: 38920052
Small molecular tool compounds play an essential role in the study of G protein-coupled receptors (GPCRs). However, tool compounds most often occupy the orthosteric binding site, hampering the study of...
7.
Dilweg M, Gorostiola Gonzalez M, de Ruiter M, Meijboom N, Veldhoven J, Liu R, et al.
Purinergic Signal
. 2024 Jun;
PMID: 38879664
The human equilibrative nucleoside transporter 1 (SLC29A1, hENT1) is a solute carrier that modulates the passive transport of nucleosides and nucleobases, such as adenosine. This nucleoside regulates various physiological processes,...
8.
Mocking T, van Oostveen W, Veldhoven J, Minnee H, Fehres C, Whitehurst C, et al.
Front Pharmacol
. 2024 May;
15:1372109.
PMID: 38783936
The prostaglandin transporter (PGT, SLCO2A1) mediates transport of prostanoids (a.o. prostaglandin E2 (PGE)) into cells and thereby promotes their degradation. Overexpression of PGT leads to low extracellular PGE levels and...
9.
den Hollander L, IJzerman A, Heitman L
Med Res Rev
. 2024 Apr;
44(5):2291-2306.
PMID: 38634664
Chemokine receptors are relevant targets for a multitude of immunological diseases, but drug attrition for these receptors is remarkably high. While many drug discovery programs have been pursued, most prospective...
10.
Gorostiola Gonzalez M, Rakers P, Jespers W, IJzerman A, Heitman L, van Westen G
Int J Mol Sci
. 2024 Apr;
25(7).
PMID: 38612509
Cancer remains a leading cause of mortality worldwide and calls for novel therapeutic targets. Membrane proteins are key players in various cancer types but present unique challenges compared to soluble...