Herman S Overkleeft
Overview
Explore the profile of Herman S Overkleeft including associated specialties, affiliations and a list of published articles.
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421
Citations
5889
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Recent Articles
1.
Ruijgrok G, Offen W, Pickles I, Raju D, Patsos T, de Boer C, et al.
J Am Chem Soc
. 2025 Feb;
147(10):8578-8586.
PMID: 39999423
During infection, the human opportunistic pathogen Pseudomonas aeruginosa forms protective biofilms, whose matrix consists of proteins, nucleic acids, and polysaccharides such as alginate, Psl, and Pel. Psl, a polymeric pentasaccharide...
2.
Uddin M, Julin K, Overkleeft H, Johannessen M, Lentz C
ACS Infect Dis
. 2025 Feb;
11(3):573-583.
PMID: 39916318
In search of new putative antimicrobial drug targets in methicillin-resistant , we aimed to identify and characterize retaining glycosidase activities in this bacterial pathogen. Using activity-based protein profiling (ABPP), a...
3.
Osterlid K, Sorieul C, Unione L, Li S, Garcia-Sepulveda C, Carboni F, et al.
J Am Chem Soc
. 2025 Jan;
147(3):2829-2840.
PMID: 39792791
is a Gram-positive bacterium that is responsible for severe nosocomial infections. The rise of multidrug-resistant strains, which can pose significant health threats, prompts the development of new treatment interventions, and...
4.
Pickles I, Chen Y, Moroz O, Brown H, de Boer C, Armstrong Z, et al.
Angew Chem Int Ed Engl
. 2024 Nov;
64(5):e202415219.
PMID: 39601378
α-Amylases are the workhorse enzymes of starch degradation. They are central to human health, including as targets for anti-diabetic compounds, but are also the key enzymes in the industrial processing...
5.
Bannink S, Bila K, van Weperen J, Ligthart N, Ferraz M, Boot R, et al.
J Lipid Res
. 2024 Oct;
65(11):100670.
PMID: 39395789
Gaucher disease (GD) is a lysosomal storage disorder (LSD) resulting from inherited glucocerebrosidase (GBA1) deficiency. GD diagnosis relies on GBA1 activity assays, typically employing 4-methylumbelliferyl-β-D-glucopyranoside (4MU-β-Glc) as fluorogenic substrate. However,...
6.
Koemans T, Bennett M, Ferraz M, Armstrong Z, Artola M, Aerts J, et al.
Chem Commun (Camb)
. 2024 Sep;
60(82):11734-11737.
PMID: 39318342
The human Golgi α-mannosidase, hGMII, removes two mannose residues from GlcNAc-ManGlcNAc to produce GlcNAcManGlcNAc, the precursor of all complex -glycans including tumour-associated ones. The natural product GMII inhibitor, swainsonine, blocks...
7.
Radchenko Y, Su Q, Schroder S, van Gijlswijk L, Artola M, Aerts J, et al.
Chemistry
. 2024 Sep;
30(70):e202402988.
PMID: 39305182
Cyclophellitol is a potent and selective mechanism-based retaining β-glucosidase inhibitor that has served as a versatile starting point for the development of activity-based glycosidase probes (ABPs). We developed routes of...
8.
Su Q, Louwerse M, Lammers R, Maurits E, Janssen M, Boot R, et al.
Chem Sci
. 2024 Sep;
PMID: 39246358
GBA2, the non-lysosomal β-glucosylceramidase, is an enzyme involved in glucosylceramide metabolism. Pharmacological inhibition of GBA2 by -alkyl iminosugars is well tolerated and benefits patients suffering from Sandhoff and Niemann-Pick type...
9.
Thaler M, Ofman T, Kok K, Heming J, Moran E, Pickles I, et al.
ACS Cent Sci
. 2024 Sep;
10(8):1594-1608.
PMID: 39220688
The combined inhibition of endoplasmic reticulum (ER) α-glucosidases I and II has been shown to inhibit replication of a broad range of viruses that rely on ER protein quality control....
10.
Artola M, Aerts J, van der Marel G, Rovira C, Codee J, Davies G, et al.
J Am Chem Soc
. 2024 Aug;
146(36):24729-24741.
PMID: 39213505
Activity-based protein profiling (ABPP) is an effective technology for the identification and functional annotation of enzymes in complex biological samples. ABP designs are normally directed to an enzyme active site...