Marc-Werner Dobenecker
Overview
Explore the profile of Marc-Werner Dobenecker including associated specialties, affiliations and a list of published articles.
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12
Citations
840
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Recent Articles
1.
Dobenecker M, Marcello J, Becker A, Rudensky E, Bhanu N, Carrol T, et al.
FEBS Lett
. 2020 Aug;
594(20):3324-3337.
PMID: 32862441
Humoral immunity in mammals relies on the function of two developmentally and functionally distinct B-cell subsets-B1 and B2 cells. While B2 cells are responsible for the adaptive response to environmental...
2.
Lee C, Holder M, Grau D, Saldana-Meyer R, Yu J, Ganai R, et al.
Mol Cell
. 2018 Apr;
70(3):435-448.e5.
PMID: 29681498
The maintenance of gene expression patterns during metazoan development is achieved, in part, by the actions of polycomb repressive complex 2 (PRC2). PRC2 catalyzes mono-, di-, and trimethylation of histone...
3.
Dobenecker M, Park J, Marcello J, McCabe M, Gregory R, Knight S, et al.
J Exp Med
. 2018 Mar;
215(4):1101-1113.
PMID: 29523590
Differentiation and activation of T cells require the activity of numerous histone lysine methyltransferases (HMT) that control the transcriptional T cell output. One of the most potent regulators of T...
4.
Dobenecker M, Kim J, Marcello J, Fang T, Prinjha R, Bosselut R, et al.
J Exp Med
. 2015 Feb;
212(3):297-306.
PMID: 25687282
The fidelity of T cell immunity depends greatly on coupling T cell receptor signaling with specific T cell effector functions. Here, we describe a chromatin-based mechanism that enables integration of...
5.
Hobeika E, Levit-Zerdoun E, Anastasopoulou V, Pohlmeyer R, Altmeier S, Alsadeq A, et al.
EMBO J
. 2015 Jan;
34(7):925-39.
PMID: 25630702
The development and function of B lymphocytes is regulated by numerous signaling pathways, some emanating from the B-cell antigen receptor (BCR). The spleen tyrosine kinase (Syk) plays a central role...
6.
Delgado-Olguin P, Dang L, He D, Thomas S, Chi L, Sukonnik T, et al.
Development
. 2014 Nov;
141(23):4610-7.
PMID: 25359725
Maintenance of vascular integrity is required for embryogenesis and organ homeostasis. However, the gene expression programs that stabilize blood vessels are poorly understood. Here, we show that the histone methyltransferase...
7.
Tanaka H, Akagi K, Oneyama C, Tanaka M, Sasaki Y, Kanou T, et al.
J Biol Chem
. 2013 Apr;
288(21):15240-54.
PMID: 23548896
Proteins with Src homology 2 (SH2) domains play major roles in tyrosine kinase signaling. Structures of many SH2 domains have been studied, and the regions involved in their interactions with...
8.
Donlin L, Andresen C, Just S, Rudensky E, Pappas C, Kruger M, et al.
Genes Dev
. 2012 Jan;
26(2):114-9.
PMID: 22241783
Protein lysine methylation is one of the most widespread post-translational modifications in the nuclei of eukaryotic cells. Methylated lysines on histones and nonhistone proteins promote the formation of protein complexes...
9.
Pereira J, Sansom S, Smith J, Dobenecker M, Tarakhovsky A, Livesey F
Proc Natl Acad Sci U S A
. 2010 Aug;
107(36):15957-62.
PMID: 20798045
Multipotent progenitor cells of the cerebral cortex balance self-renewal and differentiation to produce complex neural lineages in a fixed temporal order in a cell-autonomous manner. We studied the role of...
10.
Oneyama C, Hikita T, Enya K, Dobenecker M, Saito K, Nada S, et al.
Mol Cell
. 2008 May;
30(4):426-36.
PMID: 18498747
The tyrosine kinase c-Src is upregulated in various human cancers irrespective of its negative regulator Csk, but the regulatory mechanisms remain unclear. Here, we show that a lipid raft-anchored Csk...