Paul Delgado-Olguin
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Explore the profile of Paul Delgado-Olguin including associated specialties, affiliations and a list of published articles.
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53
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Recent Articles
1.
Perillat L, Wong T, Maino E, Ahmed A, Scott O, Hyatt E, et al.
Dis Model Mech
. 2024 Aug;
PMID: 39099311
Becker Muscular Dystrophy (BMD) is a rare X-linked recessive neuromuscular disorder frequently caused by in-frame deletions in the DMD gene that result in the production of a truncated, yet functional,...
2.
Ahmed A, Syed J, Chi L, Wang Y, Perez-Romero C, Lee D, et al.
Nat Cardiovasc Res
. 2024 Apr;
2(2):174-191.
PMID: 38665902
Cardiac metabolism is deranged in heart failure, but underlying mechanisms remain unclear. Here, we show that lysine demethylase 8 (Kdm8) maintains an active mitochondrial gene network by repressing , thus...
3.
Aharon-Yariv A, Wang Y, Ahmed A, Delgado-Olguin P
BMC Genomics
. 2023 Nov;
24(1):709.
PMID: 37996818
Background: As the fetal heart develops, cardiomyocyte proliferation potential decreases while fatty acid oxidative capacity increases in a highly regulated transition known as cardiac maturation. Small noncoding RNAs, such as...
4.
Rok M, Wong T, Maino E, Ahmed A, Yang G, Hyatt E, et al.
Mol Ther Methods Clin Dev
. 2023 Aug;
30:246-258.
PMID: 37545481
Duchenne muscular dystrophy (DMD) is a disease with a life-threatening trajectory resulting from mutations in the dystrophin gene, leading to degeneration of skeletal muscle and fibrosis of cardiac muscle. The...
5.
Aitken K, Yadav P, Sidler M, Thanabalasingam T, Ahmed T, Aggarwal P, et al.
PLoS One
. 2023 Jul;
18(7):e0287205.
PMID: 37494380
Rodents have the capacity for spontaneous bladder regeneration and bladder smooth muscle cell (BSMC) migration following a subtotal cystectomy (STC). YAP/WWTR1 and BDNF (Brain-derived neurotrophic factor) play crucial roles in...
6.
Chi L, Zhong L, Lee D, Yu X, Caballero A, Nieman B, et al.
Biol Open
. 2023 Jul;
12(8).
PMID: 37470706
G9a, also known as EHMT2, is essential for embryogenesis and has specific functions in multiple developmental processes. G9a inactivation affects development of the nervous system, which is formed with contribution...
7.
Chi L, Lee D, Leung S, Hu G, Wen B, Delgado-Olguin P, et al.
Cell Mol Life Sci
. 2023 Jun;
80(7):183.
PMID: 37338571
Peroxisomes are essential for mitochondrial health, as the absence of peroxisomes leads to altered mitochondria. However, it is unclear whether the changes in mitochondria are a function of preserving cellular...
8.
Veitch S, Njock M, Chandy M, Siraj M, Chi L, Mak H, et al.
Cardiovasc Diabetol
. 2022 Feb;
21(1):31.
PMID: 35209901
Background: Type 2 diabetes (T2D) is associated with coronary microvascular dysfunction, which is thought to contribute to compromised diastolic function, ultimately culminating in heart failure with preserved ejection fraction (HFpEF)....
9.
Wu R, Li B, Horne R, Ahmed A, Lee D, Robinson S, et al.
Mol Nutr Food Res
. 2021 Dec;
66(4):e2100893.
PMID: 34921749
Scope: Necrotizing enterocolitis (NEC) is a devastating gastrointestinal emergency affecting preterm infants. Breastmilk protects against NEC, partly due to human milk oligosaccharides (HMOs). HMO compositions are highly diverse, and it...
10.
Tokarz V, Delgado-Olguin P, Klip A
J Clin Invest
. 2021 Nov;
131(21).
PMID: 34720091
Skeletal muscle preeminently determines whole-body glycemia. However, the molecular basis and inheritable influence that drive the progression of insulin resistance to type 2 diabetes remain debated. In this issue of...