Christian Schmedt
Overview
Explore the profile of Christian Schmedt including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
1476
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0
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Recent Articles
1.
Barrow A, Cella M, Edeling M, Khan M, Cervantes-Barragan L, Bugatti M, et al.
J Immunol
. 2023 Dec;
212(3):369-374.
PMID: 38117750
NKp44 is a human receptor originally found on activated NK cells, group 1 and group 3 innate lymphoid cells that binds dimers of platelet-derived growth factor D (PDGF-DD). NKp44 is...
2.
Liu X, Wang H, Jiang Y, Zheng Q, Petrus M, Zhang M, et al.
Cell Res
. 2019 Jan;
29(2):95-109.
PMID: 30607017
Mammals possess a remarkable ability to sense subtle temperature deviations from the thermoneutral skin temperature of ~33 °C, which ensures precise warm sensation. However, the underlying mechanisms remain unclear. Here...
3.
Ting P, Parker A, Lee J, Trussell C, Sharif O, Luna F, et al.
Nat Methods
. 2018 Oct;
15(11):941-946.
PMID: 30297964
CRISPR-Cas9 screening allows genome-wide interrogation of gene function. Currently, to achieve the high and uniform Cas9 expression desirable for screening, one needs to engineer stable and clonal Cas9-expressing cells-an approach...
4.
Sampath S, Sampath S, Ho A, Corbel S, Millstone J, Lamb J, et al.
Nat Commun
. 2018 Apr;
9(1):1531.
PMID: 29670077
The balance between stem cell quiescence and proliferation in skeletal muscle is tightly controlled, but perturbed in a variety of disease states. Despite progress in identifying activators of stem cell...
5.
Ma S, Cahalan S, LaMonte G, Grubaugh N, Zeng W, Murthy S, et al.
Cell
. 2018 Mar;
173(2):443-455.e12.
PMID: 29576450
Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced Plasmodium infection in vitro;...
6.
Barrow A, Edeling M, Trifonov V, Luo J, Goyal P, Bohl B, et al.
Cell
. 2017 Dec;
172(3):534-548.e19.
PMID: 29275861
Many tumors produce platelet-derived growth factor (PDGF)-DD, which promotes cellular proliferation, epithelial-mesenchymal transition, stromal reaction, and angiogenesis through autocrine and paracrine PDGFRβ signaling. By screening a secretome library, we found...
7.
Zhang Q, Vashisht A, ORourke J, Corbel S, Moran R, Romero A, et al.
Nat Commun
. 2017 Jun;
8:15664.
PMID: 28569745
Although recent evidence has pointed to the existence of small open reading frame (smORF)-encoded microproteins in mammals, their function remains to be determined. Skeletal muscle development requires fusion of mononuclear...
8.
Miller A, Dahlberg C, Sandberg M, Wen B, Beisner D, Hoerter J, et al.
PLoS One
. 2015 Jun;
10(6):e0131071.
PMID: 26121493
Emerging approaches to treat immune disorders target positive regulatory kinases downstream of antigen receptors with small molecule inhibitors. Here we provide evidence for an alternative approach in which inhibition of...
9.
Lau J, Zhou Q, Sutton S, Herman A, Schmedt C, Glynne R
PLoS One
. 2014 Jan;
9(1):e84900.
PMID: 24454763
Aim/hypothesis: Recent studies indicate that tyrosine kinase inhibitors, including imatinib, can reverse hyperglycemia in non-obese diabetic (NOD) mice, a model of type 1 diabetes (T1D). Imatinib inhibits c-Abl, c-Kit, and...
10.
Bopp S, Rodrigo E, Gonzalez-Paez G, Frazer M, Barnes S, Valim C, et al.
Malar J
. 2013 Sep;
12:316.
PMID: 24025732
Background: One of the main causes of mortality from severe malaria in Plasmodium falciparum infections is cerebral malaria (CM). An important host genetic component determines the susceptibility of an individual...