Alexander Tarakhovsky
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Explore the profile of Alexander Tarakhovsky including associated specialties, affiliations and a list of published articles.
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77
Citations
8026
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Recent Articles
1.
Schaefer U, Miroshnikova Y, Xie W, Larson A, Lu Z, Chen S, et al.
bioRxiv
. 2025 Jan;
PMID: 39803508
Chronically persistent viruses are integral components of the organismal ecosystem in humans and animals . Many of these viruses replicate and accumulate within the cell nucleus . The nuclear location...
2.
Tarakhovsky A, Zhang T, Marina R, Veugelen S, Mander P, Prinjha R, et al.
Res Sq
. 2024 Sep;
PMID: 39281867
Nutrient deficiency during pregnancy in numerous animal species can induce the state of embryonic diapause. Diapause is characterized by changes in protein and gene expression that minimize the organism's reliance...
3.
Chandwani R, Fang T, Dewell S, Tarakhovsky A
Front Immunol
. 2023 Jun;
14:1146699.
PMID: 37275914
Introduction: Transcriptional activation depends on the interplay of chromatin modifiers to establish a permissive epigenetic landscape. While histone 3 lysine 9 (H3K9) methylation has long been associated with gene repression,...
4.
Dobenecker M, Marcello J, Becker A, Rudensky E, Bhanu N, Carrol T, et al.
FEBS Lett
. 2020 Aug;
594(20):3324-3337.
PMID: 32862441
Humoral immunity in mammals relies on the function of two developmentally and functionally distinct B-cell subsets-B1 and B2 cells. While B2 cells are responsible for the adaptive response to environmental...
5.
Nagy Z, Vogtle T, Geer M, Mori J, Heising S, Di Nunzio G, et al.
Blood
. 2018 Nov;
133(4):331-343.
PMID: 30429161
Conditional knockout (KO) mouse models are invaluable for elucidating the physiological roles of platelets. The () transgenic mouse is the current model of choice for generating megakaryocyte/platelet-specific KO mice. Platelets...
6.
Zhao N, Sebastiano V, Moshkina N, Mena N, Hultquist J, Jimenez-Morales D, et al.
Nat Struct Mol Biol
. 2018 Sep;
25(9):885-893.
PMID: 30177761
Viral infection perturbs host cells and can be used to uncover regulatory mechanisms controlling cellular responses and susceptibility to infections. Using cell biological, biochemical, and genetic tools, we reveal that...
7.
Tarakhovsky A, Prinjha R
J Exp Med
. 2018 Jun;
215(7):1777-1787.
PMID: 29934321
Humans carry trillions of viruses that thrive because of their ability to exploit the host. In this exploitation, viruses promote their own replication by suppressing the host antiviral response and...
8.
Dobenecker M, Park J, Marcello J, McCabe M, Gregory R, Knight S, et al.
J Exp Med
. 2018 Mar;
215(4):1101-1113.
PMID: 29523590
Differentiation and activation of T cells require the activity of numerous histone lysine methyltransferases (HMT) that control the transcriptional T cell output. One of the most potent regulators of T...
9.
Mori J, Nagy Z, Di Nunzio G, Smith C, Geer M, Ghaithi R, et al.
Blood
. 2018 Jan;
131(10):1122-1144.
PMID: 29301754
Src family kinases (SFKs) coordinate the initiating and propagating activation signals in platelets, but it remains unclear how they are regulated. Here, we show that ablation of C-terminal Src kinase...
10.
Razooky B, Obermayer B, Biggs OMay J, Tarakhovsky A
Genes (Basel)
. 2017 Aug;
8(8).
PMID: 28825667
Viral infection leads to a robust cellular response whereby the infected cell produces hundreds of molecular regulators to combat infection. Currently, non-canonical components, e.g., long noncoding RNAs (lncRNAs) have been...