Kevin M Nickerson
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Explore the profile of Kevin M Nickerson including associated specialties, affiliations and a list of published articles.
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16
Citations
571
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Recent Articles
1.
Gordon R, Cosgrove H, Marinov A, Gingras S, Tilstra J, Campbell A, et al.
JCI Insight
. 2024 Jul;
9(16).
PMID: 39042716
Loss of NADPH oxidase (NOX2) exacerbates systemic lupus erythematosus (SLE) in mice and humans, but the mechanisms underlying this effect remain unclear. To identify the cell lineages in which NOX2...
2.
Tilstra J, Kim M, Gordon R, Leibler C, Cosgrove H, Bastacky S, et al.
J Exp Med
. 2023 Oct;
220(12).
PMID: 37787782
Nucleic acid-specific Toll-like receptors (TLRs) have been implicated in promoting disease pathogenesis in systemic lupus erythematosus (SLE). Whether such TLRs mediate disease onset, progression, or both remains undefined; yet the...
3.
Nickerson K, Smita S, Hoehn K, Marinov A, Thomas K, Kos J, et al.
J Exp Med
. 2023 Feb;
220(5).
PMID: 36828389
Age-associated B cells (ABCs) are formed under inflammatory conditions and are considered a type of memory B cell (MBC) expressing the transcription factor T-bet. In SLE, ABC frequency is correlated...
4.
Leibler C, John S, Elsner R, Thomas K, Smita S, Joachim S, et al.
Nat Immunol
. 2022 Sep;
23(10):1457-1469.
PMID: 36151396
In lupus, Toll-like receptor 7 (TLR7) and TLR9 mediate loss of tolerance to RNA and DNA, respectively. Yet, TLR7 promotes disease, while TLR9 protects from disease, implying differences in signaling....
5.
Gordon R, Giannouli C, Raparia C, Bastacky S, Marinov A, Hawse W, et al.
JCI Insight
. 2022 Feb;
7(7).
PMID: 35192551
NADPH oxidase deficiency exacerbates lupus in murine models and patients, but the mechanisms remain unknown. It is hypothesized that NADPH oxidase suppresses autoimmunity by facilitating dead cell clearance via LC3-associated...
6.
Motwani M, McGowan J, Antonovitch J, Gao K, Jiang Z, Sharma S, et al.
Front Immunol
. 2021 Apr;
12:605930.
PMID: 33854495
Detection of DNA is an important determinant of host-defense but also a driver of autoinflammatory and autoimmune diseases. Failure to degrade self-DNA in DNAseII or III(TREX1)-deficient mice results in activation...
7.
Marinov A, Wang H, Bastacky S, van Puijenbroek E, Schindler T, Speziale D, et al.
Arthritis Rheumatol
. 2020 Dec;
73(5):826-836.
PMID: 33277983
Objective: Depleting pathogenic B cells could treat systemic lupus erythematosus (SLE). However, depleting B cells in an inflammatory setting such as lupus is difficult. This study was undertaken to investigate...
8.
Gordon R, Tilstra J, Marinov A, Nickerson K, Bastacky S, Shlomchik M
PLoS One
. 2020 Apr;
15(4):e0226396.
PMID: 32243431
Loss of tolerance to nuclear antigens and multisystem tissue destruction is a hallmark of systemic lupus erythematosus (SLE). Although the source of autoantigen in lupus remains elusive, a compelling hypothetical...
9.
Tilstra J, John S, Gordon R, Leibler C, Kashgarian M, Bastacky S, et al.
J Clin Invest
. 2020 Mar;
130(6):3172-3187.
PMID: 32191633
Toll-like receptor 9 (TLR9) is a regulator of disease pathogenesis in systemic lupus erythematosus (SLE). Why TLR9 represses disease while TLR7 and MyD88 have the opposite effect remains undefined. To...
10.
Gonzalez D, Cote C, Patel J, Smith C, Zhang Y, Nickerson K, et al.
J Immunol
. 2018 Nov;
201(12):3569-3579.
PMID: 30446568
We examined the unique contributions of the cytokines IL-21 and IL-4 on germinal center (GC) B cell initiation and subsequent maturation in a murine model system. Similar to other reports,...