Jeremy S Tilstra
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Explore the profile of Jeremy S Tilstra including associated specialties, affiliations and a list of published articles.
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21
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1151
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Recent Articles
1.
Gordon R, Cosgrove H, Marinov A, Gingras S, Tilstra J, Campbell A, et al.
JCI Insight
. 2024 Jul;
9(16).
PMID: 39042716
Loss of NADPH oxidase (NOX2) exacerbates systemic lupus erythematosus (SLE) in mice and humans, but the mechanisms underlying this effect remain unclear. To identify the cell lineages in which NOX2...
2.
Tilstra J, Kim M, Gordon R, Leibler C, Cosgrove H, Bastacky S, et al.
J Exp Med
. 2023 Oct;
220(12).
PMID: 37787782
Nucleic acid-specific Toll-like receptors (TLRs) have been implicated in promoting disease pathogenesis in systemic lupus erythematosus (SLE). Whether such TLRs mediate disease onset, progression, or both remains undefined; yet the...
3.
Cosgrove H, Gingras S, Kim M, Bastacky S, Tilstra J, Shlomchik M
JCI Insight
. 2023 Aug;
8(16).
PMID: 37606042
The endosomal Toll-like receptor 7 (TLR7) is a major driver of murine and human systemic lupus erythematosus (SLE). The role of TLR7 in lupus pathogenesis is enhanced when the regulatory...
4.
Pandey S, Bender M, McPherson A, Phelps C, Sanchez L, Rana M, et al.
Cell Host Microbe
. 2022 Jun;
30(7):1003-1019.e10.
PMID: 35658976
The triggers that drive interferon-γ (IFNγ)-producing CD8 T cell (Tc1 cell)-mediated autoimmune hepatitis (AIH) remain obscure. Here, we show that lack of hematopoietic Tet methylcytosine dioxygenase 2 (Tet2), an epigenetic...
5.
Smita S, Chikina M, Shlomchik M, Tilstra J
JCI Insight
. 2022 Mar;
7(8).
PMID: 35271505
We previously found that kidney-infiltrating T cells (KITs) in murine lupus nephritis (LN) resembled dysfunctional T cells that infiltrate tumors. This unexpected finding raised the question of how to reconcile...
6.
Gordon R, Giannouli C, Raparia C, Bastacky S, Marinov A, Hawse W, et al.
JCI Insight
. 2022 Feb;
7(7).
PMID: 35192551
NADPH oxidase deficiency exacerbates lupus in murine models and patients, but the mechanisms remain unknown. It is hypothesized that NADPH oxidase suppresses autoimmunity by facilitating dead cell clearance via LC3-associated...
7.
Gordon R, Tilstra J, Marinov A, Nickerson K, Bastacky S, Shlomchik M
PLoS One
. 2020 Apr;
15(4):e0226396.
PMID: 32243431
Loss of tolerance to nuclear antigens and multisystem tissue destruction is a hallmark of systemic lupus erythematosus (SLE). Although the source of autoantigen in lupus remains elusive, a compelling hypothetical...
8.
Tilstra J, John S, Gordon R, Leibler C, Kashgarian M, Bastacky S, et al.
J Clin Invest
. 2020 Mar;
130(6):3172-3187.
PMID: 32191633
Toll-like receptor 9 (TLR9) is a regulator of disease pathogenesis in systemic lupus erythematosus (SLE). Why TLR9 represses disease while TLR7 and MyD88 have the opposite effect remains undefined. To...
9.
Tilstra J, Avery L, Menk A, Gordon R, Smita S, Kane L, et al.
J Clin Invest
. 2018 Aug;
128(11):4884-4897.
PMID: 30130253
While T cells are important for the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis, little is known about how T cells function after infiltrating the kidney. The current...
10.
Robinson A, Yousefzadeh M, Rozgaja T, Wang J, Li X, Tilstra J, et al.
Redox Biol
. 2018 May;
17:259-273.
PMID: 29747066
Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if...