Michael Kashgarian
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Explore the profile of Michael Kashgarian including associated specialties, affiliations and a list of published articles.
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77
Citations
3691
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Recent Articles
1.
Gordon R, Cosgrove H, Marinov A, Gingras S, Tilstra J, Campbell A, et al.
JCI Insight
. 2024 Jul;
9(16).
PMID: 39042716
Loss of NADPH oxidase (NOX2) exacerbates systemic lupus erythematosus (SLE) in mice and humans, but the mechanisms underlying this effect remain unclear. To identify the cell lineages in which NOX2...
2.
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, et al.
J Clin Invest
. 2024 Mar;
134(6).
PMID: 38488004
No abstract available.
3.
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, et al.
J Clin Invest
. 2023 Jul;
133(13).
PMID: 37395276
BackgroundAcute tubulointerstitial nephritis (AIN) is one of the few causes of acute kidney injury with diagnosis-specific treatment options. However, due to the need to obtain a kidney biopsy for histological...
4.
Melchinger H, Calderon-Gutierrez F, Obeid W, Xu L, Shaw M, Luciano R, et al.
Clin J Am Soc Nephrol
. 2022 Aug;
17(9):1284-1292.
PMID: 35948365
Background And Objectives: Uromodulin, produced exclusively in the kidney's thick ascending limb, is a biomarker of kidney tubular health. However, the relationship between urine uromodulin and histologic changes in the...
5.
Meas R, Nititham J, Taylor K, Maher S, Clairmont K, Carufe K, et al.
ACR Open Rheumatol
. 2022 Jun;
4(9):760-770.
PMID: 35708944
Objective: To determine if single-nucleotide polymorphisms (SNPs) in DNA repair genes are enriched in individuals with systemic lupus erythematosus (SLE) and if they are sufficient to confer a disease phenotype...
6.
Veron D, Aggarwal P, Li Q, Moeckel G, Kashgarian M, Tufro A
Front Pharmacol
. 2022 Mar;
12:788886.
PMID: 35280251
Vascular endothelial growth factor-a (VEGF-A) and nitric oxide (NO) are essential for glomerular filtration barrier homeostasis, and are dysregulated in diabetic kidney disease (DKD). While NO availability is consistently low...
7.
Moledina D, Eadon M, Calderon F, Yamamoto Y, Shaw M, Perazella M, et al.
Nephrol Dial Transplant
. 2021 Dec;
37(11):2214-2222.
PMID: 34865148
Background: Patients with acute interstitial nephritis (AIN) can present without typical clinical features, leading to a delay in diagnosis and treatment. We therefore developed and validated a diagnostic model to...
8.
Paluri S, Burak M, Senejani A, Levinson M, Rahim T, Clairmont K, et al.
DNA Repair (Amst)
. 2021 Jun;
105:103152.
PMID: 34186496
The Polb gene encodes DNA polymerase beta (Pol β), a DNA polymerase that functions in base excision repair (BER) and microhomology-mediated end-joining. The Pol β-Y265C protein exhibits low catalytic activity...
9.
Moledina D, Wilson F, Kukova L, Obeid W, Luciano R, Kuperman M, et al.
Nephrol Dial Transplant
. 2020 Oct;
36(10):1851-1858.
PMID: 33125471
Background: We previously demonstrated that urine interleukin (IL)-9 and tumor necrosis factor (TNF)-α can distinguish acute interstitial nephritis (AIN) from other causes of acute kidney injury. Here we evaluated the...
10.
Tilstra J, John S, Gordon R, Leibler C, Kashgarian M, Bastacky S, et al.
J Clin Invest
. 2020 Mar;
130(6):3172-3187.
PMID: 32191633
Toll-like receptor 9 (TLR9) is a regulator of disease pathogenesis in systemic lupus erythematosus (SLE). Why TLR9 represses disease while TLR7 and MyD88 have the opposite effect remains undefined. To...