Mark J Shlomchik
Overview
Explore the profile of Mark J Shlomchik including associated specialties, affiliations and a list of published articles.
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160
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11606
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Recent Articles
1.
Prado D, Cattley R, Sonego A, Sutariya P, Wu S, Lee M, et al.
J Exp Med
. 2024 Dec;
222(2).
PMID: 39738812
T helper 17 (Th17) cells are effector cells that mediate inflammatory responses to bacterial and fungal pathogens. While the cytokine signaling inputs required to generate Th17s are established, less is...
2.
Gordon R, Cosgrove H, Marinov A, Gingras S, Tilstra J, Campbell A, et al.
JCI Insight
. 2024 Jul;
9(16).
PMID: 39042716
Loss of NADPH oxidase (NOX2) exacerbates systemic lupus erythematosus (SLE) in mice and humans, but the mechanisms underlying this effect remain unclear. To identify the cell lineages in which NOX2...
3.
Elsner R, Smita S, Shlomchik M
Nat Immunol
. 2024 Jun;
25(7):1283-1295.
PMID: 38862796
While some infections elicit germinal centers, others produce only extrafollicular responses. The mechanisms controlling these dichotomous fates are poorly understood. We identify IL-12 as a cytokine switch, acting directly on...
4.
Omelchenko A, Siwek J, Chhibbar P, Arshad S, Nazarali I, Nazarali K, et al.
bioRxiv
. 2024 May;
PMID: 38746274
The explosion of sequence data has allowed the rapid growth of protein language models (pLMs). pLMs have now been employed in many frameworks including variant-effect and peptide-specificity prediction. Traditionally, for...
5.
Tilstra J, Kim M, Gordon R, Leibler C, Cosgrove H, Bastacky S, et al.
J Exp Med
. 2023 Oct;
220(12).
PMID: 37787782
Nucleic acid-specific Toll-like receptors (TLRs) have been implicated in promoting disease pathogenesis in systemic lupus erythematosus (SLE). Whether such TLRs mediate disease onset, progression, or both remains undefined; yet the...
6.
Cosgrove H, Gingras S, Kim M, Bastacky S, Tilstra J, Shlomchik M
JCI Insight
. 2023 Aug;
8(16).
PMID: 37606042
The endosomal Toll-like receptor 7 (TLR7) is a major driver of murine and human systemic lupus erythematosus (SLE). The role of TLR7 in lupus pathogenesis is enhanced when the regulatory...
7.
Nickerson K, Smita S, Hoehn K, Marinov A, Thomas K, Kos J, et al.
J Exp Med
. 2023 Feb;
220(5).
PMID: 36828389
Age-associated B cells (ABCs) are formed under inflammatory conditions and are considered a type of memory B cell (MBC) expressing the transcription factor T-bet. In SLE, ABC frequency is correlated...
8.
Abboud G, Choi S, Zhang X, Park Y, Kanda N, Zeumer-Spataro L, et al.
J Immunol
. 2023 Jan;
210(4):377-388.
PMID: 36602759
The activation of lymphocytes in patients with lupus and in mouse models of the disease is coupled with an increased cellular metabolism in which glucose plays a major role. The...
9.
Leibler C, John S, Elsner R, Thomas K, Smita S, Joachim S, et al.
Nat Immunol
. 2022 Sep;
23(10):1457-1469.
PMID: 36151396
In lupus, Toll-like receptor 7 (TLR7) and TLR9 mediate loss of tolerance to RNA and DNA, respectively. Yet, TLR7 promotes disease, while TLR9 protects from disease, implying differences in signaling....
10.
Langley W, Wieland A, Ahmed H, Rasheed M, Davis C, Sewatanon J, et al.
J Virol
. 2022 Apr;
96(9):e0002622.
PMID: 35404084
Humoral immunity is a major component of the adaptive immune response against viruses and other pathogens with pathogen-specific antibody acting as the first line of defense against infection. Virus-specific antibody...