Jaime L Cullen
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Explore the profile of Jaime L Cullen including associated specialties, affiliations and a list of published articles.
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10
Citations
238
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Recent Articles
1.
Florsheim E, Bachtel N, Cullen J, Lima B, Godazgar M, Carvalho F, et al.
Nature
. 2023 Jul;
620(7974):643-650.
PMID: 37437602
In addition to its canonical function of protection from pathogens, the immune system can also alter behaviour. The scope and mechanisms of behavioural modifications by the immune system are not...
2.
Nundel K, Mande P, Moses S, Busto P, Cullen J, Schmidt M, et al.
J Immunol
. 2019 Sep;
203(8):2055-2062.
PMID: 31534009
The AM14 BCR, derived from an autoimmune MRL/lpr mouse, binds autologous IgG2aa/j with low affinity, and as a result, AM14 B cells only proliferate in response to IgG2a immune complexes...
3.
Sweet R, Nickerson K, Cullen J, Wang Y, Shlomchik M
J Immunol
. 2017 Jun;
199(3):885-893.
PMID: 28659358
MyD88 and FcR common γ-chain (Fcer1g, FcRγ) elicit proinflammatory responses to exogenous Ags. Deletion of these receptors in autoimmune models has generally led to reduced overall disease. In B cells,...
4.
Ols M, Cullen J, Turqueti-Neves A, Giles J, Shlomchik M
Immunity
. 2016 Oct;
45(5):1052-1065.
PMID: 27793595
The extrafollicular (EF) plasmablast response to self-antigens that contain Toll-like receptor (TLR) ligands is prominent in murine lupus models and some bacterial infections, but the inhibitors and activators involved have...
5.
Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus
Teichmann L, Cullen J, Kashgarian M, Dong C, Craft J, Shlomchik M
Immunity
. 2015 Mar;
42(3):552-65.
PMID: 25786178
The inducible T cell costimulator (ICOS) is a potent promoter of organ inflammation in murine lupus. ICOS stimulates T follicular helper cell differentiation in lymphoid tissue, suggesting that it might...
6.
Giltiay N, Lu Y, Cullen J, Jorgensen T, Shlomchik M, Li X
J Immunol
. 2013 Aug;
191(5):2155-63.
PMID: 23904159
Self-reactive B cells in BALB/c AM14 transgenic (Tg) rheumatoid factor mice are not subject to central or peripheral tolerization. Instead, they remain at a stage of "clonal ignorance"; that is,...
7.
Nickerson K, Cullen J, Kashgarian M, Shlomchik M
J Immunol
. 2013 Mar;
190(8):3889-94.
PMID: 23467932
TLR9 suppresses TLR7-driven pathogenesis in the MRL.Fas(lpr) murine model of systemic lupus erythematosus, but the mechanisms by which TLR7 promotes and TLR9 prevents disease in this and other lupus models...
8.
Sweet R, Cullen J, Shlomchik M
J Immunol
. 2013 Feb;
190(5):1974-81.
PMID: 23365079
B cells are critical in the initiation and maintenance of lupus. Autoreactive B cells clonally expand, isotype switch, and mutate--properties associated with memory B cells (MBCs), which are typically generated...
9.
Nickerson K, Christensen S, Cullen J, Meng W, Luning Prak E, Shlomchik M
J Immunol
. 2013 Jan;
190(4):1447-56.
PMID: 23296704
Nucleic acid-reactive B cells frequently arise in the bone marrow but are tolerized by mechanisms including receptor editing, functional anergy, and/or deletion. TLR9, a sensor of endosomal dsDNA, both promotes...
10.
Sweet R, Ols M, Cullen J, Viehmann Milam A, Yagita H, Shlomchik M
Proc Natl Acad Sci U S A
. 2011 Apr;
108(19):7932-7.
PMID: 21518858
Extrafollicular (EF) B-cell responses are increasingly being recognized as an alternative pathway of B-cell activation, particularly in autoimmunity. Critical cellular interactions required for the EF B-cell response are unclear. A...