Judith Murray-Rust
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Explore the profile of Judith Murray-Rust including associated specialties, affiliations and a list of published articles.
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17
Citations
814
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Recent Articles
1.
Plaza-Menacho I, Barnouin K, Goodman K, Martinez-Torres R, Borg A, Murray-Rust J, et al.
Mol Cell
. 2014 Feb;
53(5):738-51.
PMID: 24560924
To decipher the molecular basis for RET kinase activation and oncogenic deregulation, we defined the temporal sequence of RET autophosphorylation by label-free quantitative mass spectrometry. Early autophosphorylation sites map to...
2.
Kjaer S, Linch M, Purkiss A, Kostelecky B, Knowles P, Rosse C, et al.
Biochem J
. 2013 Feb;
451(2):329-42.
PMID: 23418854
The aPKC [atypical PKC (protein kinase C)] isoforms ι and ζ play crucial roles in the formation and maintenance of cell polarity and represent attractive anti-oncogenic drug targets in Ras-dependent...
3.
Boeda B, Knowles P, Briggs D, Murray-Rust J, Soriano E, Garvalov B, et al.
J Biol Chem
. 2011 Feb;
286(13):11543-54.
PMID: 21278383
Actin-related proteins (Arps) are a highly conserved family of proteins that have extensive sequence and structural similarity to actin. All characterized Arps are components of large multimeric complexes associated with...
4.
Mayahi L, Mason L, Bleasdale-Barr K, Donald A, Trender-Gerhard I, Sweeney M, et al.
Circ Cardiovasc Genet
. 2010 Oct;
3(6):513-22.
PMID: 20937667
Background: (6R)-5,6,7,8-Tetrahydro-l-biopterin (BH4) is a cofactor for enzymes involved in catecholamine and nitric oxide generation whose synthesis is initiated by GTP cyclohydrolase I (GTPCH-1), encoded by GCH1. In the absence...
5.
Mologni L, Rostagno R, Brussolo S, Knowles P, Kjaer S, Murray-Rust J, et al.
Bioorg Med Chem
. 2010 Feb;
18(4):1482-96.
PMID: 20117004
The synthesis, structure-activity relationships (SAR) and structural data of a series of indolin-2-one inhibitors of RET tyrosine kinase are described. These compounds were designed to explore the available space around...
6.
Shadan S, Holic R, Carvou N, Ee P, Li M, Murray-Rust J, et al.
Traffic
. 2008 Jul;
9(10):1743-56.
PMID: 18636990
Of many lipid transfer proteins identified, all have been implicated in essential cellular processes, but the activity of none has been demonstrated in intact cells. Among these, phosphatidylinositol transfer proteins...
7.
Kirk R, Laman H, Knowles P, Murray-Rust J, Lomonosov M, Meziane E, et al.
J Biol Chem
. 2008 May;
283(32):22325-35.
PMID: 18495667
F-box proteins are the substrate-recognition components of the Skp1-Cul1-F box protein (SCF) E3 ubiquitin ligases. Here we report a structural relationship between Fbxo7, a component of the SCF(Fbxo7) E3 ligase,...
8.
Leiper J, Nandi M, Torondel B, Murray-Rust J, Malaki M, OHara B, et al.
Nat Med
. 2007 Feb;
13(2):198-203.
PMID: 17273169
Asymmetric dimethylarginine (ADMA) and monomethyl arginine (L-NMMA) are endogenously produced amino acids that inhibit all three isoforms of nitric oxide synthase (NOS). ADMA accumulates in various disease states, including renal...
9.
Knowles P, Murray-Rust J, Kjaer S, Scott R, Hanrahan S, Santoro M, et al.
J Biol Chem
. 2006 Aug;
281(44):33577-87.
PMID: 16928683
The RET proto-oncogene encodes a receptor tyrosine kinase for the glial cell line-derived neurotrophic factor family of ligands. Loss-of-function mutations in RET are implicated in Hirschsprung disease, whereas activating mutations...
10.
Newman M, Murray-Rust J, Lally J, Rudolf J, Fadden A, Knowles P, et al.
EMBO J
. 2005 Feb;
24(5):895-905.
PMID: 15719018
The XPF/Mus81 structure-specific endonucleases cleave double-stranded DNA (dsDNA) within asymmetric branched DNA substrates and play an essential role in nucleotide excision repair, recombination and genome integrity. We report the structure...