Shamshad Cockcroft
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Explore the profile of Shamshad Cockcroft including associated specialties, affiliations and a list of published articles.
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71
Citations
1338
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Recent Articles
1.
Cockcroft S
Adv Biol Regul
. 2024 Oct;
95:101056.
PMID: 39406587
PITPNC1 was the last of the PITPs to be identified and has been characterized as a binding protein for phosphatidylinositol and phosphatidate. In mammals, PITPNC1 is expressed as two splice...
2.
Leishman S, Aljadeed N, Qian L, Cockcroft S, Behmoaras J, Anand P
Cell Rep
. 2024 Jul;
43(8):114516.
PMID: 39024103
Despite its significance, the role of lipid metabolism in NLRP3 inflammasome remains elusive. Here, we reveal a critical role for fatty acid synthase (FASN) in NLRP3 inflammasome activation. We demonstrate...
3.
Cockcroft S
Biochim Biophys Acta Mol Cell Biol Lipids
. 2023 Sep;
1869(2):159394.
PMID: 37714261
Phosphoinositides are phosphorylated derivatives of phosphatidylinositol, a phospholipid that is synthesised at the endoplasmic reticulum. The plasma membrane contains the enzymes to phosphorylate phosphatidylinositol and is therefore rich in the...
4.
Zhao L, Thorsheim C, Suzuki A, Stalker T, Min S, Krishnaswamy S, et al.
Blood Adv
. 2023 Mar;
7(16):4233-4246.
PMID: 36930803
Platelets use signal transduction pathways facilitated by class I phosphatidylinositol transfer proteins (PITPs). The 2 mammalian class I PITPs, PITPα and PITPβ, are single PITP domain soluble proteins that are...
5.
Stastny D, Petriskova L, Tahotna D, Bauer J, Pokorna L, Holic R, et al.
FEBS Lett
. 2022 Dec;
597(4):504-514.
PMID: 36482167
Yeast Sec14-like phosphatidylinositol transfer proteins (PITPs) contain a hydrophobic cavity capable of accepting a single molecule of phosphatidylinositol (PI) or another molecule in a mutually exclusive manner. We report here...
6.
Hamilton C, Olona A, Leishman S, MacDonald-Ramsahai K, Cockcroft S, Larrouy-Maumus G, et al.
Immunohorizons
. 2022 Aug;
6(8):642-659.
PMID: 36038196
Imbalance in lipid homeostasis is associated with discrepancies in immune signaling and is tightly linked to metabolic disorders. The diverse ways in which lipids impact immune signaling, however, remain ambiguous....
7.
Padinjat R, Cockcroft S
Biochim Biophys Acta Mol Cell Biol Lipids
. 2022 Mar;
1867(6):159152.
PMID: 35314362
No abstract available.
8.
Cockcroft S
Essays Biochem
. 2021 Aug;
65(5):813-845.
PMID: 34415021
Lipids are essential constituents of cellular membranes. Once regarded merely as structural components, lipids have taken centre stage with the discovery of their roles in cell signalling and in the...
9.
Ashlin T, Blunsom N, Cockcroft S
Biochim Biophys Acta Mol Cell Biol Lipids
. 2021 Jun;
1866(9):158985.
PMID: 34111527
Phosphatidylinositol is the parent lipid for the synthesis of seven phosphorylated inositol lipids and each of them play specific roles in numerous processes including receptor-mediated signalling, actin cytoskeleton dynamics and...
10.
Katan M, Cockcroft S
Prog Lipid Res
. 2020 Sep;
80:101065.
PMID: 32966869
Phosphoinositide-specific phospholipase Cs (PLCs) are expressed in all mammalian cells and play critical roles in signal transduction. To obtain a comprehensive understanding of these enzymes in physiology and pathology, a...